Results 141 to 150 of about 56,967 (294)

Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum, McCarlie‐Jayne Dohrmann, Lucia McCarthy, Milli McMenamin, Liam A. O'Callaghan   +4 more
wiley   +1 more source

Development and Validation of a LC‐MS/MS Method for Ripretinib and Its Metabolite: Example of a Journey From Laboratory Bench to Routine Application With a Greenness Assessment

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Therapeutic drug monitoring of protein kinase inhibitors is widely practiced worldwide. Based on the example of ripretinib dosage requested by a clinician, we detailed the process of method development, using a literature‐based approach while ensuring the sustainability of the method to be as environmentally friendly as possible.
Cedric Rakotovao, Ahmad Sharanek, Audrey Burban, Paul Gueroue, Stéphane Bouchet, Guillaume Bouguéon, Dominique Ducint, Mathieu Molimard, Antoine Italiano, Sarah Djabarouti, Joris Guyon   +10 more
wiley   +1 more source

Decrease in core temperature as an indication of cholinergic overdrive during amitriptyline withdrawal [PDF]

, 1987
Steven C. Dilsaver, Mark J. Majchrzak
openalex   +1 more source

Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MSn System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma

Drug Testing and Analysis, Volume 17, Issue 9, Page 1502-1515, September 2025.
Simultaneous qualitative and quantitative analysis of 62 drugs and seven active metabolites in human blood plasma by automated liquid chromatography linear ion trap mass spectrometry. ABSTRACT Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of ...
Selina Hemmer, Maximilian Ninnig, Lea Wagmann, Sascha K. Manier, Markus R. Meyer   +4 more
wiley   +1 more source

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

Drug Testing and Analysis, Volume 17, Issue 9, Page 1772-1784, September 2025.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel, Sylvia E. Escher, Emanuel Weiler, Anke Londenberg, Uwe Deppenmeier, Rhys Whomsley   +5 more
wiley   +1 more source

Drug points: Acute polyradiculoneuropathy after amitriptyline overdose [PDF]

, 1987
Jerome Marley
openalex   +1 more source

Somatosensory Profile of Central Post Stroke Pain of Thalamic Origin: Findings of a Quantitative Sensory Testing Study

European Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Introduction Central post stroke pain (CPSP) is attributed to vascular lesions of the central somatosensory system, including the thalamus. Objective A better characterisation of clinical findings in patients with CPSP after thalamic stroke can facilitate research and treatment of this refractory pain syndrome.
Kristel Berati, Lukas Enz, Priska Zuber, Katarina Alexandra Ebner, Shaumiya Sellathurai, Kean Schoenholzer, Federico Burguet Villena, Laura Gaetano, Ludwig Kappos, Stefano Magon, Till Sprenger, Athina Papadopoulou   +11 more
wiley   +1 more source

National Prescribing Trends and Cost Analysis of Antidepressants, Anxiolytics, and Hypnotics in England, 2010–2023

Human Psychopharmacology: Clinical and Experimental, Volume 40, Issue 5, September 2025.
ABSTRACT Introduction We describe prescribing of anxiolytics/hypnotics/antidepressants at an all‐England level between 2010 and 2023, taking account of the influence of the COVID‐19 pandemic‐period. Methods All Primary Care Prescribing data for England for anxiolytics/hypnotics/antidepressant agents taken as tablets or capsules from 1 January 2010 to ...
Mike Stedman, Mark Davies, John Warner‐ Levy, Joseph Ingram, David Taylor, Adrian Heald   +5 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potential of the Antidepressant Amitriptyline against Leishmania (Leishmania) amazonensis. [PDF]

ACS Omega
Mesquita JT, Taniwaki NN, Tempone AG, Reimão JQ.   +3 more
europepmc   +1 more source

Cardiac Arrest in a Young Woman Treated with Amitriptyline Combined with Levopromazine [PDF]

, 1982
Robert T Hese
openalex   +1 more source