Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]
Korean Journal of Anesthesiology, 2019 Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim +8 more
doaj +1 more source
Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis [PDF]
, 2020 Background: Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-thecounter products.
Brueckle, Maria-Sophie +9 more
core +1 more source
Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
Respiratory Research, 2023 Introduction The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocorticoids, long-acting ß2 ...
Paulina Hempel +11 more
doaj +1 more source
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa.
PLoS ONE, 2020 BackgroundInappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was prescribed potentially ...
Renier Coetzee +3 more
doaj +1 more source
Journal of Applied Veterinary Sciences, 2023 Acetylcholinesterase is required as an enzyme to counteract the effects of acetylcholine. The aim of the study is to assess how amitriptyline and Ashwagandha affect the acetylcholinesterase gene in rat salivary glands.
Ismail R. Idrees +2 more
doaj +1 more source
Frontiers in Pain Research, 2022 Burning mouth syndrome (BMS) is defined by chronic oral burning sensations without any corresponding abnormalities. Besides amitriptyline, aripiprazole has been reported as a possible medication to manage BMS.
Motoko Watanabe +12 more
doaj +1 more source
Comparison of Duloxetine Supplemented With Pregabalin and Amitriptyline Supplemented With Pregabalin for the Treatment of Postherpetic Neuralgia: A Double-Blind, Randomized Crossover Trial. [PDF]
CNS Neurosci TherWang Y +9 more
europepmc +3 more sources
Frontiers in Physiology, 2018 Anti-depressant treatment has been found to be associated with the development of Brugada syndrome (BrS) through poorly defined mechanisms. Herein, this study aimed to explore the molecular basis for amitriptyline-induced BrS.
Xi Chen +10 more
doaj +1 more source
Biochemical and immunocytochemical studies of the testicular alteration caused by Amitriptyline in adult male rat [PDF]
Journal of Bioscience and Applied Research, 2018 Amitriptyline is one of the first reference tricyclic antidepressants (TCAs) with sedative and analgesic properties. This study aimed to investigate the testicular indices that influenced by amitriptyline treatment and examined it by biochemical ...
Ehab Tousson +3 more
doaj +1 more source
Balkan Medical Journal, 2016 Background: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. Aims: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between ...
Nil Hocaoğlu +5 more
doaj +1 more source