Results 31 to 40 of about 24,814 (247)

Mechanisms of the Cardiotoxic Action of Amitriptyline

Общая реаниматология, 2011
Objective: to study the mechanisms of toxic action of amitriptyline on the myocardium. Material and methods. Investigations were conducted using the hearts from 30 outbred albino rats, which had been isolated and perfused according to the procedure ...
G. V. Chekmarev, V. T. Dolgikh
doaj   +1 more source

Evaluation the effect of amitriptyline and/or ashwagandha on body weight in male rats

Al-SalamJournal for Medical Science, 2023
study aims to examine and compare the effects of amitriptyline and ashwagandha on body weight in male rats by measurement weight for 4 weeks after their exposure to these two compound.
Ghada A. Taqa, Ismail R. Idrees
doaj   +1 more source

Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study

Advances in Pharmacological Sciences, 2015
The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone ...
Gaurav Gupta, Tay Jia Jia, Lim Yee Woon, Dinesh Kumar Chellappan, Mayuren Candasamy, Kamal Dua   +5 more
doaj   +1 more source

Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

BMC Neurology, 2012
Background Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes.
Cheng Kuang-I, Wang Hung-Chen, Chang Lin-Li, Wang Fu-Yen, Lai Chung-Sheng, Chou Chao-Wen, Tsai Hung-Pei, Kwan Aij-Lie   +7 more
doaj   +1 more source

Level of therapeutic innovation from the registration studies of the new drugs for the prophylaxis of migraine

Journal of Clinical Pharmacy and Therapeutics, Volume 47, Issue 12, Page 2130-2139, December 2022., 2022
The new monoclonal antibodies of the class of CGRP targeting therapies have been authorized with efficacy data only against placebo. They do not offer additional clinical benefits compared to available therapies for the prevention of migraine attacks, with the exception of a lower frequency of administration.
Domenico Motola, Greta Santi Laurini, Giulia Bonaldo, Nicola Montanaro   +3 more
wiley   +1 more source

Calcium channel blocker-induced depression: a case report from South India

Open Journal of Psychiatry and Allied Sciences, 2019
Flunarizine is a cerebro-selective calcium channel blocker, commonly prescribed for migraine prophylaxis and is considered as non-inferior to propranolol to reduce the frequency of migraine attacks.
Sumana Gundam, Keya Das
doaj   +1 more source

Acute small fiber neuropathy after Oxford‐AstraZeneca ChAdOx1‐S vaccination: A report of three cases and review of the literature

Journal of the Peripheral Nervous System, Volume 27, Issue 4, Page 325-329, December 2022., 2022
Abstract Small fiber neuropathy usually presents with gradual and progressive chronic length‐dependent pain. Acute small fiber neuropathy is rarely reported. Three patients with acute onset neuropathic pain after Oxford‐AstraZeneca ChAdOx1‐S vaccination are described.
Molly G. Abbott, Zahra Allawi, Monika Hofer, Olaf Ansorge, Stefen Brady, Ricardo Fadic, Gustavo Torres, Ravi Knight, Margarita Calvo, David L. H. Bennett, Andreas C. Themistocleous   +10 more
wiley   +1 more source

A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia

Biomedicines, 2017
Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have ...
Kim Lawson
doaj   +1 more source

Pregabalin and amitriptyline as monotherapy or as low-dose combination in patients of neuropathic pain: A randomized, controlled trial to evaluate efficacy and safety in an Eastern India teaching hospital

Annals of Indian Academy of Neurology, 2019
Objectives: The main objective is to compare efficacy and safety of pregabalin and amitriptyline monotherapy with their low-dose combination in patients of neuropathic pain (NeuP).
Sourav Chakrabarty, Samar Biswas, Tamoghna Maiti, Abhijit Das, Ananya Mandal, Prasun Banerjee   +5 more
doaj   +1 more source

Effects of the Antidepressant Amitriptyline on Juvenile Brown Trout and Their Modulation by Microplastics

Toxics, 2022
Pharmaceuticals such as antidepressants are designed to be bioactive at low concentrations. According to their mode of action, they can also influence non-target organisms due to the phylogenetic conservation of molecular targets.
Hannah Schmieg, Stefanie Krais, Kathrin Kübler, Aki S. Ruhl, Isabelle M. Schmidgall, Christian Zwiener, Heinz-R. Köhler, Rita Triebskorn   +7 more
doaj   +1 more source