Results 41 to 50 of about 42,887 (227)
Mechanisms of the Cardiotoxic Action of Amitriptyline
Общая реаниматология, 2011 Objective: to study the mechanisms of toxic action of amitriptyline on the myocardium. Material and methods. Investigations were conducted using the hearts from 30 outbred albino rats, which had been isolated and perfused according to the procedure ...
G. V. Chekmarev, V. T. Dolgikh
doaj +1 more source
Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. [PDF]
PLoS ONE, 2011 Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence.
Wayne Chadwick +11 more
doaj +1 more source
Antidepressants versus placebo for depression in primary care [PDF]
, 2009 Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce +7 more
core +3 more sources
PLoS ONE, 2020 Chronic pain and sleep have a bidirectional relationship that promotes a vicious circle making chronic pain more difficult to treat. Therefore, pain and sleep should be treated simultaneously.
Hisakatsu Ito +5 more
doaj +1 more source
Toxics, 2022 Pharmaceuticals such as antidepressants are designed to be bioactive at low concentrations. According to their mode of action, they can also influence non-target organisms due to the phylogenetic conservation of molecular targets.
Hannah Schmieg +7 more
doaj +1 more source
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Update on medication-overuse headache and its treatment [PDF]
, 2015 OPINION STATEMENT: Medication-overuse headache-i.e., a too-frequent consumption of acute headache medications leading to increased headache frequency and reduced effectiveness of acute and preventive treatments-is a serious medical condition whose ...
Giamberardino MA +2 more
core +1 more source
Drug poisonings following bariatric surgery: Case series report
British Journal of Clinical Pharmacology, EarlyView.Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari +3 more
wiley +1 more source
Annals of Indian Academy of Neurology, 2019 Objectives: The main objective is to compare efficacy and safety of pregabalin and amitriptyline monotherapy with their low-dose combination in patients of neuropathic pain (NeuP).
Sourav Chakrabarty +5 more
doaj +1 more source
The Comparison of Gabapentin and Amitriptilin Effectivity as Pain Therapy in Herniated Nucleus Pulposus [PDF]
, 2015 Herniated nucleus pulposus (HNP) is one of peripheral neuropathic pain. Although concensus guidelines for the treatment of neuropathic pain are based on the results of the RCT studies, there are still gaps in the literatures.
Cahyaningsih, I. (Indriastuti) +2 more
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