Results 41 to 50 of about 47,538 (286)

Emerging pharmacotherapy of tinnitus [PDF]

, 2009
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen, Azevedo AA, Bahmad FM, Berthold Langguth, Busto U, Courtney KR, Domeisen H, Feder R, Gananca MM, Goebel G, Goodnick PJ, Gresser U, Guitton MJ, Guitton MJ, Hastak SM, Henry JA, Hilton M, Holstein N, House JW, Kuchar DL, Langguth B, Lenarz T, Mahadevan S, Mardini MK, McCabe BF, Melcher JR, Moller AR, Moller AR, Newman CW, Oliver D, Podoshin L, Richard Salvi, Rogawski MA, Roth SH, Schlee W, Shambaugh GE, Shea JJ, Shulman A, Sieghart W, Tandon R, Wei BPC, Williams SH, Willow M, Zapp JJ   +43 more
core   +1 more source

Oral burning with dysphagia and weight loss [PDF]

, 2015
Fibromyalgia is a disorder characterized by an abnormal pain regulation. Widespread pain, fatigue, and sleep disturbance are the prevalent symptoms.
CALO', LORENZO, ROSSI, GIANPAOLO, ROSSITTO, GIACOMO, SECCIA, TERESA MARIA   +3 more
core   +1 more source

Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. [PDF]

PLoS ONE, 2011
Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence.
Wayne Chadwick, Nick Mitchell, Jenna Caroll, Yu Zhou, Sung-Soo Park, Liyun Wang, Kevin G Becker, Yongqing Zhang, Elin Lehrmann, William H Wood, Bronwen Martin, Stuart Maudsley   +11 more
doaj   +1 more source

Mechanisms of the Cardiotoxic Action of Amitriptyline

Общая реаниматология, 2011
Objective: to study the mechanisms of toxic action of amitriptyline on the myocardium. Material and methods. Investigations were conducted using the hearts from 30 outbred albino rats, which had been isolated and perfused according to the procedure ...
G. V. Chekmarev, V. T. Dolgikh
doaj   +1 more source

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Effects of the Antidepressant Amitriptyline on Juvenile Brown Trout and Their Modulation by Microplastics

Toxics, 2022
Pharmaceuticals such as antidepressants are designed to be bioactive at low concentrations. According to their mode of action, they can also influence non-target organisms due to the phylogenetic conservation of molecular targets.
Hannah Schmieg, Stefanie Krais, Kathrin Kübler, Aki S. Ruhl, Isabelle M. Schmidgall, Christian Zwiener, Heinz-R. Köhler, Rita Triebskorn   +7 more
doaj   +1 more source

Initiation of Psychotropic Medication after Partner Bereavement: A Matched Cohort Study [PDF]

, 2013
Background Recent changes to diagnostic criteria for depression in DSM-5 remove the bereavement exclusion, allowing earlier diagnosis following bereavement.
A Bourke, AL Forte, Christina R. Victor, Derek G. Cook, DM Fick, DS Davydow, E Bui, EL Fosbøl, G Brown, Iain M. Carey, J Glass, J Möller, J Warner, James Coyne, JC Wakefield, JD Lewis, JM Cook, M Stroebe, ME Charlson, R Mojtabai, S Zisook, S Zisook, SM Shah, SM Shah, SM Shah, Stephen DeWilde, Sunil M. Shah, Tess Harris   +27 more
core   +3 more sources

Pharmacogenomic testing and its future in community pharmacy [PDF]

, 2020
Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core   +1 more source

Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.

PLoS ONE, 2020
Chronic pain and sleep have a bidirectional relationship that promotes a vicious circle making chronic pain more difficult to treat. Therefore, pain and sleep should be treated simultaneously.
Hisakatsu Ito, Yoshinori Takemura, Yuta Aoki, Mizuki Hattori, Hideyo Horikawa, Mitsuaki Yamazaki   +5 more
doaj   +1 more source

Antidepressants versus placebo for depression in primary care [PDF]

, 2009
Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce, Blashki, Grant, Elley, C. Raina, Fishman, Tana, Goodyear-Smith, Felicity A., Kenealy, Tim, Kerse, Ngaire, MacGillivray, Stephen   +7 more
core   +3 more sources