Results 81 to 90 of about 56,967 (294)
Antidepressants in the Management of Chronic Pain Syndromes [PDF]
, 1990 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90213/1/j.1875-9114.1990.tb02582.x ...
Chaffee, Betty J., Egbunike, Ifeanyi G.
core +1 more source
Patterns of Analgesic Prescribing and High‐Risk Prescribing in Primary Care in Ireland 2014–2022—A Repeated Cross‐Sectional Study [PDF]
Eur J PainABSTRACT Background Pain is a significant burden on individuals, healthcare systems and society. Analgesic drugs carry many therapeutic benefits; however, all drugs are associated with adverse effects and risk of harm. Non‐steroidal anti‐inflammatory drugs (NSAIDs) and opioids have been identified as particularly high‐risk due to the risk of side ...
Mattsson M +10 more
europepmc +2 more sources
Brain Pathology, EarlyView.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Safety implications of low-dose amitriptyline in neuropathic pain [PDF]
, 2019 Background: Treatment guidelines in neuropathic pain list amitriptyline as a first-line option. Modest evidence on efficacy and safety concerns possibly shape the rationale behind dosing recommendations.
Borg, John Joseph +6 more
core +1 more source
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, EarlyView.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]
, 2019 Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core
A single dose of hypnotic corrects sleep and EEG abnormalities in symptomatic Huntington's disease mice. [PDF]
, 2016 Sleep and electroencephalogram abnormalities are prominent early features of Huntington's disease (HD) that typically appear before the onset of characteristic motor symptoms.
Kantor, Sandor +2 more
core +2 more sources
Structure‐based discovery of thiamine uptake inhibitors
British Journal of Pharmacology, EarlyView.Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel +2 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Sleep disturbances and epilepsy are closely interrelated. This study aimed to examine associations between sleep quality, affective symptoms, and quality of life (QoL) in people with epilepsy (PWE), and to identify clinical and sociodemographic factors linked to impaired sleep. Methods We conducted a multicenter cross‐sectional study
Johann Philipp Zöllner +11 more
wiley +1 more source