Results 71 to 80 of about 4,707 (142)

Coma Blisters, Peripheral Neuropathy, and Amitriptyline Overdose: A Brief Report

open access: yes, 2002
Background: Coma blisters are most commonly associated with barbiturate and benzodiazepine overdose; however, they have also been described in association with many other substances, including amitriptyline.
Sheilagh Maguiness   +2 more
core   +1 more source

Amitriptyline influences the mechanical withdrawal threshold in bone cancer pain rats by regulating glutamate transporter GLAST

open access: yesMolecular Pain, 2019
Patients with cancer, especially breast, prostate, and lung cancer, commonly experience bone metastases that are difficult to manage and are associated with bone cancer pain. Amitriptyline is often used to treat chronic pain, such as neuropathic pain. In
Simeng Ma   +7 more
doaj   +1 more source

Hemoperfusion in a child with amitriptyline intoxication

open access: yes, 2005
Tricyclic antidepressant overdose is one of the most common causes of serious drug poisoning in children and adults. We report a 17-month-old girl with severe amitriptyline intoxication. She was admitted to hospital because of lethargy and seizures.

core   +1 more source

The Neuraxial Effects of Intraspinal Amitriptyline at Low Concentrations

open access: yes, 2015
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)BACKGROUND: As a result of amitriptyline's vast array of actions, it could potentially be used as an intraspinal adjuvant in neuraxial anesthesia and/or in the treatment of refractory ...
Ganem, EM   +4 more
core   +1 more source

Amitriptyline inhibits the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes

open access: yes, 2009
Objectives Evidence suggests that glutamatergic systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants.
Hee-Jung Baika   +3 more
core   +1 more source

Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms

open access: yesJournal of Spectroscopy, 2013
The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN− complex on addition of the drug amitriptyline forms the basis of ...
Pankaj Soni, Deepak Sinha, Rajmani Patel
doaj   +1 more source

The role of adenosine receptors on amitriptyline-induced electrophysiological changes on rat atrium

open access: yes, 2013
We investigated the role of adenosine receptors in amitriptyline-induced cardiac action potential (AP) changes in isolated rat atria. In the first group, APs were recorded after cumulative addition of amitriptyline (1 mu M, 10 mu M and 50 mu M). In other
Bal, I   +12 more
core   +1 more source

Antidepressant amitriptyline‐induced matrix metalloproteinase‐9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line‐derived neurotrophic factor mRNA expression in rat astroglial cells

open access: yesNeuropsychopharmacology Reports, 2019
Background Astrocytes have been implicated in the pathophysiology of mood disorders and in the mechanism of the pharmacological effects of antidepressant drugs by the production of neurotrophic/growth factors.
Hiromi Abe   +5 more
doaj   +1 more source

Analysis of amitriptyline overdose in emergency medicine

open access: yes, 2011
Introduction Amitriptyline is a tricyclic antidepressant. In general, toxicity effects develop within 30 min of overdose and peak from 2 h to 6 h. Anticholinergic effects predominate in cases of low dose ingestion. In cases of high dose ingestion, marked
Altunci, Yusuf Ali   +3 more
core   +1 more source

Amitriptyline versus other types of pharmacotherapy for depression

open access: yes, 2003
Background: For many years amitriptyline has been considered one of the reference compounds for the pharmacological treatment of depression. However, new tricyclic drugs, heterocyclic compounds and the selective serotonin reuptake inhibitors have been ...
C Barbui   +5 more
core   +1 more source

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