Results 81 to 90 of about 29,828 (259)

GC/MS determination of gabapentin in human plasma and vitreous humor and its application to forensic samples

Journal of Forensic Sciences, EarlyView.
Abstract Gabapentin (GBP) is widely prescribed off‐label, and cases of misuse, abuse, self‐medication, and intentional self‐harm have been reported. This study aimed to develop and validate a simple GC‐MS method for the determination of GBP in plasma and vitreous humor (VH) and to explore the relationship between concentrations in both matrices in ...
Pamela Cabarcos‐Fernández, Inés Sánchez‐Sellero, Iván Álvarez‐Freire, María Jesús Tabernero‐Duque, Ana María Bermejo‐Barrera   +4 more
wiley   +1 more source

In vitro and in vivo modulation of LPS and carrageenan-induced expression of inflammatory genes by amitriptyline [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2017
Context: Amitriptyline, a tricyclic antidepressant is used for the management of psychological disorders and various types of pain. In the previous work, it is founded that amitriptyline inhibited the migration of polymorphonuclear (PMN) into the site of
Laleh Rafiee, Valiollah Hajhashemi, Shaghayegh Haghjooy Javanmard   +2 more
doaj  

The role of adenosine receptors on amitriptyline-induced electrophysiological changes on rat atrium

, 2013
We investigated the role of adenosine receptors in amitriptyline-induced cardiac action potential (AP) changes in isolated rat atria. In the first group, APs were recorded after cumulative addition of amitriptyline (1 mu M, 10 mu M and 50 mu M). In other
Bal, I, Kalkan, S, Bal, I. B., Kalkan, S., Kalkan, ŞULE, Iskit, ALPER BEKTAŞ, Oransay, K, Oransay, K., Sara, Y, Sara, Y., Iskit, A. B., Ertunc, M., Ertunc, M   +12 more
core   +1 more source

Indications for amitriptyline according to Standard Treatment Guidelines[14, 15].

, 2020
Indications for amitriptyline according to Standard Treatment Guidelines[14, 15].
Mosedi Namane (8735610), Renier Coetzee (8735601), Yasmina Johnson (8735604), Johan van Niekerk (8735607)   +3 more
core   +1 more source

Imagery rescripting for generalized anxiety disorder: A case series

British Journal of Clinical Psychology, EarlyView.
Abstract Introduction This is the first clinical pilot to explore the feasibility, acceptability and preliminary efficacy of imagery rescripting in individuals with a diagnosis of generalized anxiety disorder (GAD). Methods Participants with GAD (N = 18) attended assessment and 10 weekly sessions of imagery rescripting with a psychologist in person or ...
L. Stavropoulos, A. B. Phipps, I. Sabel, D. D. J. Cooper, N. Briggs, J. M. Newby, J. R. Grisham   +6 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

Cellular Physiology and Biochemistry, 2013
Background/Aims: Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the
Lutz Nährlich, Jochen G. Mainz, Constantin Adams, Corinna Engel, Gloria Herrmann, Vanya Icheva, Josefine Lauer, Caroline Deppisch, Andreas Wirth, Katy Unger, Ute Graepler-Mainka, Andreas Hector, Susanne Heyder, Martin Stern, Gerd Döring, Erich Gulbins, Joachim Riethmüller   +16 more
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Acute Eosinophilic Pneumonia Associated with Amitriptyline in a Hemodialysis Patient

, 2001
Drugs are well known causes of eosinophilic lung disease. In many patients, drug-induced eosinophilic lung disease presents with transient eosinophilic infiltrates that disappear after discontinuation of the drug.
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core   +1 more source