Results 81 to 90 of about 219,440 (288)
EBioMedicine, 2023 Summary: Background: Short- and long-term implications of SARS-CoV-2 on the quality of the sperm and the results of this on fertility remain largely unknown due to lack of longitudinal studies.
Christophe Depuydt +6 more
doaj
Novel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy
Drug Delivery, 2021 CD123 targeting molecules have been widely applied in acute myelocytic leukemia (AML) therapeutics. Although antibodies have been more widely used as targeting molecules, aptamer have unique advantages for CD123 targeting therapy.
Haibin Wu +8 more
doaj +1 more source
A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis [PDF]
, 2017 DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated.
Anqi Liu +17 more
core +1 more source
AML: Predicting the Unpredictable [PDF]
Cell Stem Cell, 2018 Acute myeloid leukemia (AML) has been considered an unpredictable and unpreventable disease. Recently in Nature, Abelson et al. (2018) presented two models of AML risk prediction, one using the detection of high-risk age-related clonal hematopoiesis and the other using dynamic clinical attributes available from routine blood work.
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.A kirigami‐inspired breathable smart contact lens is reported for wireless monitoring of corneal hypoxia and microenvironment. The ultrathin (55 µm) and flexible sensing device enables digitalized, in situ and precise monitoring of dissolved oxygen, humidity, and temperature (R2 >0.98).
Jiaxue Zhu +11 more
wiley +1 more source
Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells [PDF]
, 2004 The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist.
Grandage, V.L. +3 more
core +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Lifting the differentiation embargo [PDF]
, 2016 Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al.
Holyoake, Tessa, Latif, Anne-Louise
core +1 more source
Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells
Advanced Healthcare Materials, EarlyView.Cell membrane nanoparticles made with stromal cells are prepared and used to target leukemia cells. Deposition of the cell membrane onto rigid silica cores leads to increased uptake both in leukemia cell lines and primary cells from patients. These results show that nanoparticle rigidity affects the interaction between cell membrane nanoparticles and ...
Sander de Weerd +8 more
wiley +1 more source
Clustering of settling microswimmers in turbulence [PDF]
Nonlinear Processes in GeophysicsClustering of plankton plays a vital role in several biological activities, including feeding, predation, and mating. Gyrotaxis is one of the mechanisms that induces clustering.
J. Qiu +4 more
doaj +1 more source