Results 11 to 20 of about 70,737 (298)

Anticancer Effects of Amlodipine Alone or in Combination With Gefitinib in Non-Small Cell Lung Cancer

Frontiers in Pharmacology, 2022
Amlodipine is a Ca2+ channel blocker commonly used to cardiovascular diseases such as hypertension and angina; however, its anticancer effects in lung cancer A549 cells remain unknown. In the present study, we explored the antitumor effects and molecular
Bingjie Fu, Xiaojing Dou, Miao Zou, Hao Lu, Kaixuan Wang, Qingxia Liu, Yao Liu, Wei Wang, Meihua Jin, Dexin Kong   +9 more
doaj   +2 more sources

Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism

Pharmaceutical Biology, 2020
Context Hyperlipidaemia and hypertension are often treated together with curcumin and amlodipine. It is necessary to investigate the drug-drug interaction between curcumin and amlodipine.
Na Jiang, Meicheng Zhang, Xiangzhi Meng, Bin Sun   +3 more
doaj   +2 more sources

Quantum chemistry calculation aided design of chiral ionic liquid-based extraction system for amlodipine separation [PDF]

AIChE Journal, 2018
Amlodipine is a widely used medication in treating hypertension, which is also known as a chiral compound. So far efforts have been made to obtain optically pure (S)-amlodipine because (R)-amlodipine has poor efficacy and is ...
Becke, Bhattacharyya, Boys, Cao, Cui, Dong, Fileti, Fileti, Frisch, Fumio, Gong, Gotrane, Grimme, Holbach, Kapnissi-Christodoulou, Keith, Kimaru, Latosińska, Lee, Lee, Meng, Meredith, Parr, Peng, Po, Schuur, Sesin, Sun, Sun, Sunsandee, Tang, Tang, Tang, Tao, Wang, Wu, Wu, Xie, Xing, Yang, Yang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao   +48 more
core   +2 more sources

IS-10506 probiotic administration increases amlodipine absorption in a rabbit model

Journal of International Medical Research, 2018
Objective Probiotics are beneficial in human health. In this study, we investigated the effect of probiotics on absorption of amlodipine, a dihydropyridine calcium antagonist used in the treatment of angina and hypertension, in a rabbit model.
Febrina A. Saputri, Devinna Kang, Arif S. W. Kusuma, Taofik Rusdiana, Aliya N. Hasanah, Mutakin, Ingrid S. Surono, Hiroshi Koyama, Rizky Abdulah   +8 more
doaj   +2 more sources

Amlodipine in the current management of hypertension

The Journal of Clinical Hypertension, 2023
Hypertension is the leading cause of death worldwide, affecting 1.4 billion people. Treatment options include the widely used calcium channel blockers, among which amlodipine, a dihydropyridine, has unique characteristics that distinguish it from other ...
Ji-Guang Wang, B. Palmer, Katherine Vogel Anderson, P. Sever   +3 more
semanticscholar   +1 more source

Amlodipine inhibits proliferation, invasion, and colony formation of breast cancer cells.

Biomedical Reports, 2022
Calcium channel upregulation has been implicated in cancer cell proliferation and progression including in breast cancer. Fortunately, the function of calcium channels can be manipulated pharmacologically using calcium channel blockers (CCBs). Amlodipine,
Mohammad A. Y. Alqudah, Raneem Al-Samman, Marwah Azaizeh, K. Alzoubi   +3 more
semanticscholar   +1 more source

Life-Threatening Amlodipine Overdose: A Rare Case of Noncardiogenic Pulmonary Edema and Respiratory Failure Requiring ICU Care. [PDF]

Clin Case Rep
ABSTRACT Amlodipine, a dihydropyridine calcium channel blocker (CCB), is commonly prescribed for hypertension and anginal chest pain. An overdose of this medication can result in life‐threatening complications such as vasodilatory shock and pulmonary edema. Noncardiogenic pulmonary edema in this setting is rare and not well understood.
Pandit R, Masuta P, Regmi N, Nepali A, Acharya G, Jibran M, Maharjan H, Shrestha N.   +7 more
europepmc   +2 more sources

Amlodipine, an anti‐hypertensive drug, alleviates non‐alcoholic fatty liver disease by modulating gut microbiota

British Journal of Pharmacology, 2021
Non‐alcoholic fatty liver disease (NAFLD) represents a severe public health problem. It often coexists with hypertension in the context of metabolic syndrome.
Yang Li, Danyang Zhao, Min-yi Qian, Jun Liu, Chu-yue Pan, Xinxin Zhang, Xu-bin Duan, Yufei Zhang, Wenxin Jia, Lirui Wang   +9 more
semanticscholar   +1 more source

Comparison of losartan and amlodipine effects on the outcomes of patient with COVID‐19 and primary hypertension: A randomised clinical trial

International journal of clinical practice, 2021
Controversy exists regarding the drug selection in hypertension (HTN) management in patients with COVID‐19. This study aimed to compare the effects of losartan and amlodipine in patients with primary HTN and COVID‐19.
Masoud Nouri-vaskeh, Niusha Kalami, R. Zand, Zahra Soroureddin, M. Varshochi, K. Ansarin, H. Rezaee, A. Taghizadieh, A. Sadeghi, Masoud Ahangari Maleki, Azam Esmailnajad, Parviz Saleh, M. Haghdoost, M. Maleki, A. Sharifi   +14 more
semanticscholar   +1 more source

Dual-Targeted Therapy in Cardiometabolic Risk: A Meta-Analysis of Telmisartan-Based Combinations for Hypertension and Dyslipidemia. [PDF]

Clin Cardiol
ABSTRACT Background Hypertension often coexists with dyslipidemia, requiring combination therapy. Telmisartan, combined with amlodipine or rosuvastatin, targets these conditions. This meta‐analysis evaluates the efficacy and safety of these combinations in adults with hypertension and dyslipidemia.
Asim R, Muhammad TS, Ahmed S, Khurram L, Azeem B, Doggar ME, Muhammad AN, Chikatimalla R, Kapaganti S, Chigurupati HD, Qureshi B, Sandhyavenu H, Neppala S.   +12 more
europepmc   +2 more sources