Results 111 to 120 of about 17,783 (291)

A New Handheld Device for the Detection of Falsified Medicines: Demonstration on Falsified Artemisinin-Based Therapies from the Field. [PDF]

, 2017
Poor-quality medicines are a major problem for health-care systems in resource-poor settings as identifying falsified medicines requires a complex laboratory infrastructure such as a Medicines Quality Control Laboratory. We report here an evaluation of a
Allan, Elizabeth Louise, Bell, David, Kaur, Harparkash, Lozama, Anthony, Wilson, Benjamin K   +4 more
core   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Amodiaquine

Definitions, 2020
An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum ...

semanticscholar   +1 more source

Evaluating the effectiveness and cost‐effectiveness of integrating mass drug administration for helminth control with seasonal malaria chemoprevention in Ghanaian children: Protocol for a cluster randomised controlled trial

Tropical Medicine &International Health, Volume 30, Issue 1, Page 22-30, January 2025.
Abstract Objectives To evaluate the effectiveness and cost‐effectiveness of integrating seasonal malaria chemoprevention (SMC) with mass drug administration for helminth control among school‐aged children living in communities where the burden of malaria and helminths is high in Ghana, West Africa.
Muhammed O. Afolabi, Dennis Adu‐Gyasi, Lucy Paintain, Theresa Tawiah, Mohammed Sanni Ali, Brian Greenwood, Kwaku Poku Asante   +6 more
wiley   +1 more source

Hematoxicity of amodiaquine in sprague-dawley rats

Toxicology International, 2012
The use of amodiaquine (AQ) and its associated toxic effect has been a major public health concern since cases of life-threatening agranulocytosis and hepatic toxicity were reported during its prophylactic use. The objective of this study was to evaluate the hematological safety profile of AQ therapy.Sprague-Dawley rats were randomly distributed into ...
RE Akhigbe, AO Akinola, O. M. Azeez, W. A. Saka   +3 more
openaire   +3 more sources

Do Health Workers' Preferences Influence their Practices? Assessment of Providers' Attitude and Personal use of new Treatment Recommendations for Management of Uncomplicated Malaria, Tanzania. [PDF]

, 2012
\ud \ud Due to growing antimalarial drug resistance, Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006,
Khatib, Rashid A, Lutambi, Angelina M, Masanja, Irene M   +2 more
core   +3 more sources

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K, Nzila, A, Ochong, E, van den Broek, I   +3 more
core   +1 more source

Use of area under the curve to evaluate the effects of antimalarial drugs on malaria associated anemia after treatment [PDF]

, 2011
To evaluate the effects of antimalarial drugs on Plasmodium falciparum malaria associated anemia (MAA), we use the area under curve (AUC) of anemia levels after treatment as an approach to combine their duration and magnitude.
Fatunmbi, Bayo, Folarin, Onikepe A, Gbotosho, Grace O., Happi, Christian T., Michael, Obaro S, Okuboyejo, Titilope M, Sowunmi, Akintunde   +6 more
core   +1 more source

Tissue Distribution and Excretion of Amodiaquine in the Rat

Journal of Pharmacy and Pharmacology, 1988
Abstract 14C-Labelled amodiaquine ([14C]AQ) has been administered to male Wistar rats by oral and intravenous routes (n = 6 for each route of administration). Excretion of total 14C-activity was predominantly in the faeces after both oral and intravenous administration.
C. G. Curtis, Alasdair Breckenridge, G. M. Powell, Peter Winstanley, M.L'e. Orme, Geoffrey Edwards   +5 more
openaire   +3 more sources

Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine [PDF]

, 2014
Amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use.
Babaei, H., Eghbal, M.A., Heidari, R.
core   +1 more source