Results 271 to 280 of about 17,480 (292)

Effects of amodiaquine, artesunate, and artesunate–amodiaquine on Plasmodium falciparum malaria-associated anaemia in children

Acta Tropica, 2009
The effects of amodiaquine, artesunate and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia (PfMAA) and the recovery from PfMAA were evaluated in 328 children with uncomplicated malaria randomized to the standard dose regimens of the three drug treatments.
S T Balogun, Grace O. Gbotosho, Christian T. Happi, Akintunde Sowunmi   +3 more
openaire   +3 more sources

The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson’s disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway

Metabolic brain disease, 2021
P. Kambey, Chengcheng Ma, Xiaoxiao Guo, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Gao   +7 more
semanticscholar   +1 more source

Amodiaquine Resistant Falciparum Malaria in Thailand

The American Journal of Tropical Medicine and Hygiene, 1975
Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand. Chloroquine cured 0% (0/13). The cure rates with amodiaquine were the same whether a 1.5 g or 2.0 g course was used. Most patients were resistant to amodiaquine at the RI level and to chloroquine at the RII level.
P. Phintuyothin, A.P. Hall, Herbert E. Segal, S. Kosakal, Eliot J. Pearlman   +4 more
openaire   +3 more sources

EFFECTS OF AMODIAQUIN AND QUINIDINE ON CARDIAC CONDUCTION

Canadian Journal of Physiology and Pharmacology, 1965
The effects of the antiarrhythmia agents amodiaquin and quinidine on conduction times through the atrium and the specialized conducting tissue to the ventricular myocardium have been determined from records obtained with needle electrodes suitably placed in isolated blood perfused dog hearts.
Bryan W. Kirk, Peter E. Dresel
openaire   +3 more sources

Investigation of amodiaquine localization in liver lobules using matrix-assisted laser desorption/ionization imaging mass spectrometry.

Rapid Communications in Mass Spectrometry, 2019
RATIONALE High mass and high spatial resolution matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) opens new possibilities for the detailed study of the hepatic metabolism of drugs.
Kerri J. Grove, Shaila Hoque, P. Rudewicz   +2 more
semanticscholar   +1 more source

Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

CrysteEngComm, 2019
A new polymorph of amodiaquine dihydrochloride dihydrate was obtained via heterogenous crystallization. This new polymorph showed difference in two-dimensional sheet structure compare to previously known polymorph.

semanticscholar   +1 more source

Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial

The Lancet, 2005
Many countries in Africa are considering a change to combination treatment for falciparum malaria because of the increase in drug resistance. However, there are few effectiveness data for these combinations. Our aim was to study the effectiveness of three drug combinations that have proven efficacious in east Africa compared with amodiaquine ...
Rachel Hallett, Jalal Uddin Ahmed, Chris Drakeley, Archie Heller, Christopher J. M. Whitty, Brian Greenwood, Devota Anthony, Theonest K. Mutabingwa, Theonest K. Mutabingwa   +8 more
openaire   +3 more sources

Mechanism of amodiaquine-induced supersensitivity to catecholamines

European Journal of Pharmacology, 1969
Abstract Small doses of amodiaquine moderately potentiated the pressor responses to adrenaline, noradrenaline and tyramine in anaesthetized dogs and rabbits and in spinal or pithed vagotomized dogs. In spinal or pithed animals the tachycardia produced by adrenaline was also augmented.
M.N. Jindal, K.H. Pandya, V.V. Kelkar
openaire   +3 more sources

The safety of amodiaquine use in pregnant women

Expert Opinion on Drug Safety, 2007
Few antimalarial drugs have been evaluated extensively in pregnancy because of fears over toxicity. However, increasing Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine makes finding alternative antimalarials that are safe and effective in pregnancy a priority.
Daniel Chandramohan, Brian Greenwood, Harry Tagbor   +2 more
openaire   +3 more sources

Amodiaquine and Hydroxychloroquine Resistance in Plasmodium falciparum

The American Journal of Tropical Medicine and Hygiene, 1961
Summary and Conclusions A strain of Plasmodium falciparum from the Magdalena Valley, Colombia, South America, which is resistant to chloroquine, has been shown to be resistant also to amodiaquine (Camoquin®) and to hydroxychloroquine (Plaquenil®), which are other members of the 4-aminoquinoline group.
openaire   +3 more sources