Results 271 to 280 of about 17,783 (291)

Amodiaquine Resistant Falciparum Malaria in Thailand

The American Journal of Tropical Medicine and Hygiene, 1975
Amodiaquine cured 38% (13/34) of patients with falciparum malaria in Southeast Thailand. Chloroquine cured 0% (0/13). The cure rates with amodiaquine were the same whether a 1.5 g or 2.0 g course was used. Most patients were resistant to amodiaquine at the RI level and to chloroquine at the RII level.
P. Phintuyothin, A.P. Hall, Herbert E. Segal, S. Kosakal, Eliot J. Pearlman   +4 more
openaire   +3 more sources

The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson’s disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway

Metabolic brain disease, 2021
P. Kambey, Chengcheng Ma, Xiaoxiao Guo, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Gao   +7 more
semanticscholar   +1 more source

Investigation of amodiaquine localization in liver lobules using matrix-assisted laser desorption/ionization imaging mass spectrometry.

Rapid Communications in Mass Spectrometry, 2019
RATIONALE High mass and high spatial resolution matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) opens new possibilities for the detailed study of the hepatic metabolism of drugs.
Kerri J. Grove, Shaila Hoque, P. Rudewicz   +2 more
semanticscholar   +1 more source

Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

CrysteEngComm, 2019
A new polymorph of amodiaquine dihydrochloride dihydrate was obtained via heterogenous crystallization. This new polymorph showed difference in two-dimensional sheet structure compare to previously known polymorph.

semanticscholar   +1 more source

Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial

The Lancet, 2005
Many countries in Africa are considering a change to combination treatment for falciparum malaria because of the increase in drug resistance. However, there are few effectiveness data for these combinations. Our aim was to study the effectiveness of three drug combinations that have proven efficacious in east Africa compared with amodiaquine ...
Rachel Hallett, Jalal Uddin Ahmed, Chris Drakeley, Archie Heller, Christopher J. M. Whitty, Brian Greenwood, Devota Anthony, Theonest K. Mutabingwa, Theonest K. Mutabingwa   +8 more
openaire   +3 more sources

The safety of amodiaquine use in pregnant women

Expert Opinion on Drug Safety, 2007
Few antimalarial drugs have been evaluated extensively in pregnancy because of fears over toxicity. However, increasing Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine makes finding alternative antimalarials that are safe and effective in pregnancy a priority.
Daniel Chandramohan, Brian Greenwood, Harry Tagbor   +2 more
openaire   +3 more sources

Amodiaquine and Hydroxychloroquine Resistance in Plasmodium falciparum

The American Journal of Tropical Medicine and Hygiene, 1961
Summary and Conclusions A strain of Plasmodium falciparum from the Magdalena Valley, Colombia, South America, which is resistant to chloroquine, has been shown to be resistant also to amodiaquine (Camoquin®) and to hydroxychloroquine (Plaquenil®), which are other members of the 4-aminoquinoline group.
openaire   +3 more sources

Unusual Toxic Manifestations to Amodiaquin (Camoquin)

Archives of Dermatology, 1958
A 42-year-old white woman, with chronic, discoid lupus erythematosus of 12 years' duration, was found to be intolerant (acute gastroenteritis) of all previously tried antimalarials. Because of recent reports 1 on the use of amodiaquin (Camoquin) it was felt judicious to institute such therapy in this patient.
openaire   +3 more sources

Development of pharmaceutically scalable inhaled anti-cancer nanotherapy - Repurposing amodiaquine for non-small cell lung cancer (NSCLC).

Materials Science and Engineering C: Materials for Biological Applications, 2020
Vineela Parvathaneni, N. Kulkarni, G. Chauhan, Snehal K. Shukla, Rasha S. Elbatanony, Brijeshkumar S. Patel, N. Kunda, A. Muth, Vivek Gupta   +8 more
semanticscholar   +1 more source

Ultrasensitive voltammetric detection of an antimalarial drug (amodiaquine) at a disposable and low cost electrode

Chemical Monthly, 2020
Serkan Karakaya, B. Kartal, Y. Dilgin
semanticscholar   +1 more source