Results 21 to 30 of about 17,708 (290)

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

ChemMedChem, 2022
Several lines of evidence suggest the ligand‐sensing transcription factor Nurr1 as a promising target to treat neurodegenerative diseases. Nurr1 modulators to validate and exploit this therapeutic potential are rare, however.
Sabine Willems, Marcel Müller, Julia Ohrndorf, J. Heering, E. Proschak, D. Merk   +5 more
semanticscholar   +1 more source

Dolutegravir pharmacokinetics during co-administration with either artemether/lumefantrine or artesunate/amodiaquine.

Journal of Antimicrobial Chemotherapy, 2021
BACKGROUND In sub-Saharan Africa, artemisinin-containing therapies for malaria treatment are regularly co-administered with ART. Currently, dolutegravir-based regimens are recommended as first-line therapy for HIV across most of Africa.
A. Kawuma, S. Walimbwa, G. Pillai, S. Khoo, M. Lamorde, R. Wasmann, P. Denti   +6 more
semanticscholar   +1 more source

Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates

Journal of Antimicrobial Chemotherapy, 2021
Background Expanding resistance to multiple antimalarials, including chloroquine, in South-East Asia (SEA) urges the development of new therapies.
F. Nardella, Mélissa Mairet-Khedim, C. Roesch, S. Maher, Sopheakvatey Ke, R. Leang, D. Leroy, B. Witkowski   +7 more
semanticscholar   +1 more source

Pharmacokinetics of intravenous amodiaquine. [PDF]

British Journal of Clinical Pharmacology, 1987
Amodiaquine hydrochloride (3 mg base kg‐1) was given by constant rate intravenous injection over 10 min to seven healthy adult male volunteers, and by constant rate infusion (10 mg base kg‐1) over 4 h to 10 adult patients admitted to hospital with falciparum malaria.
White, N, Looareesuwan, S, Edwards, G, Phillips, R, Karbwang, J, Nicholl, D, Bunch, C, Warrell, D   +7 more
openaire   +4 more sources

Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia

Clinical Infectious Diseases, 2020
Background Artesunate-amodiaquine is a potential therapy for uncomplicated malaria in Cambodia. Methods Between September 2016 and January 2017, artesunate-amodiaquine efficacy and safety were evaluated in a prospective, open-label, single-arm ...
Mélissa Mairet-Khedim, R. Leang, Camille Marmai, N. Khim, Saorin Kim, Sopheakvatey Ke, Chhayleang Kauy, Nimol Kloeung, Rotha Eam, Sophy Chy, B. Izac, Denis Mey Bouth, Maria Dorina Bustos, P. Ringwald, F. Ariey, B. Witkowski   +15 more
semanticscholar   +1 more source

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

BMC Medicine, 2020
The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also widely used as part of seasonal malaria ...
M. Bretscher, P. Dahal, J. Griffin, K. Stepniewska, Q. Bassat, E. Baudin, U. d’Alessandro, A. Djimde, G. Dorsey, E. Espié, Bakary Fofana, R. González, E. Juma, C. Karema, E. Lasry, B. Lell, N. Lima, C. Menéndez, G. Mombo-Ngoma, C. Moreira, Frederic Nikiema, J. Ouédraogo, S. Staedke, H. Tinto, I. Valéa, Adoke Yeka, A. Ghani, P. Guérin, L. Okell   +28 more
semanticscholar   +1 more source

Oral amodiaquine microparticles repurposed for the treatment of visceral leishmaniasis

Scientific African, 2022
Background: Leishmaniasis, a neglected tropical disease, is caused by parasites from the genus Leishmania and transmitted by the female phlebotamine sandfly.
Henry Nettey, Isaac Joe Erskine, Afia Antwi Mensah, Nana Kwame Ofori Gyamera, Charles Kwadwo Obuobi, Doris Kumadoh, Isaac Julius Asiedu-Gyekye, Grace Lovia Allotey-Babington   +7 more
doaj   +1 more source

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources

Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers

Antimicrobial Agents and Chemotherapy, 2020
High rates of artemisinin-based combination therapy (ACT) failures in the treatment of Plasmodium falciparum malaria in Southeast Asia have led to triple-drug strategies to extend the useful life of ACTs.
C. X. Anh, M. Chavchich, G. Birrell, K. van Breda, T. Travers, K. Rowcliffe, A. Lord, G. Shanks, M. Edstein   +8 more
semanticscholar   +1 more source

Amodiaquine promotes testosterone production and de novo synthesis of cholesterol and triglycerides in Leydig cells

Journal of Lipid Research, 2021
Testosterone is a hormone essential for male reproductive function. It is produced primarily by Leydig cells in the testicle through activation of steroidogenic acute regulatory protein and a series of steroidogenic enzymes, including a cytochrome P450 ...
Yujeong Choi, Eun Goo Lee, Gibbeum Lee, Mi Gyeong Jeong, Hyo Kyeong Kim, Ji-Hyun Oh, Sung Won Kwon, Eun Sook Hwang   +7 more
doaj   +1 more source