Results 61 to 70 of about 15,045 (253)

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source

Eficacia terapéutica y eventos adversos de tratamientos para malaria vivax y malaria falciparum en gestantes en las regiones de Urabá y Alto San Jorge, Colombia, 2008-2011 Therapeutic efficacy and adverse events of treatments for vivax and falciparum malaria in pregnant women in the regions of Uraba and Alto San Jorge, Colombia, 2008-2011

Revista Colombiana de Obstetricia y Ginecología, 2013
Objetivo: evaluar, con el protocolo de la Organización Mundial de la Salud (OMS) de 1998, la respuesta terapéutica antimalárica (RTA) y los eventos adversos (EA) en cuatro esquemas de tratamiento antiplasmodial en gestantes colombianas, con diagnóstico ...
Jaime Carmona-Fonseca, Olga María Agudelo-García, Eliana Arango-Flórez   +2 more
doaj  

Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. Las relaciones de la gametocitemia de Plasmodium falciparum con el tratamiento antipalúdico han sido poco estudiadas en América. Objetivo.
Jaime Carmona-Fonseca, Eliana Arango, Silvia Blair   +2 more
doaj   +1 more source

Do Health Workers' Preferences Influence their Practices? Assessment of Providers' Attitude and Personal use of new Treatment Recommendations for Management of Uncomplicated Malaria, Tanzania. [PDF]

, 2012
\ud \ud Due to growing antimalarial drug resistance, Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006,
Khatib, Rashid A, Lutambi, Angelina M, Masanja, Irene M   +2 more
core   +3 more sources

The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro‐Inflammatory Macrophages

Scandinavian Journal of Immunology, Volume 102, Issue 5, November 2025.
Nurr1 activation in human primary macrophages induced the increment of PPARγ expression through protein stabilisation and reduction of the proportion of PPARγ phosphorylated at Ser84, a repressive mark for PPARγ transcriptional activity. The Nurr1 agonist C‐DIM12 enhanced the rosiglitazone‐induced expression of PPARγ‐responsive genes. ABSTRACT Nurr1 is
Eduardo Santana‐Cisneros, Miguel A. Solís‐Barbosa, Norma C. Segovia‐Gamboa, Marco A. Meraz‐Ríos, Erika González‐Domínguez, Rosaura Hernández‐Rivas, Daniel Marrero‐Rodríguez, Carmen Sanchez‐Torres   +7 more
wiley   +1 more source

Eficacia de la combinación amodiaquina más sulfadoxinapirimetamina y de la cloroquina para el tratamiento del paludismo en Córdoba, Colombia, 2006

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La disminución de la eficacia de los medicamentos antipalúdicos en el mundo y en Colombia, dificulta el control de la enfermedad. Objetivo.
Manuel Alberto Pérez, Liliana Jazmín Cortés, Ángela Patricia Guerra, Angélica Knudson, Carlos Usta, Rubén Santiago Nicholls   +5 more
doaj   +1 more source

Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana

Malaria Journal, 2020
Background Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs may affect treatment outcome ...
Peter Hodoameda, Nancy Odurowah Duah-Quashie, Charles Oheneba Hagan, Sena Matrevi, Benjamin Abuaku, Kwadwo Koram, Neils Ben Quashie   +6 more
doaj   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source

Efikasi Obat Kloroquine, Kina, Artesunate-SP, Artesunate-Amodiaquine, Artesunate-Lumafentrin pada Anak Malaria Falciparum di BLU RSUP Prof. Dr. RD. Kandou Manado

Sari Pediatri, 2016
Latar belakang. Malaria falciparum masih merupakan salah satu penyebab utama kematian dan kesakitan pada anak-anak dan orang dewasa di negara-negara tropis.
Suryadi Nicolaas Napoleon Tatura
doaj   +1 more source

Response to Buffet et al: Intermittent preventive anti-malarial treatment to children (IPTc): firebreak or fire trap?

, 2008
Buffet and colleagues have reviewed some of the potential benefits and drawbacks of intermittent preventive antimalarial treatment in children (IPTc).
Bojang, Kalifa, Chandramohan, Daniel, Cisse, Badara, Greenwood, Brian, Kweku, Margaret, Milligan, Paul   +5 more
core   +1 more source