Results 61 to 70 of about 15,149 (207)

Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana

open access: yesMalaria Journal, 2020
Background Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs may affect treatment outcome ...
Peter Hodoameda   +6 more
doaj   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

open access: yes, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K   +3 more
core   +1 more source

Response to Buffet et al: Intermittent preventive anti-malarial treatment to children (IPTc): firebreak or fire trap?

open access: yes, 2008
Buffet and colleagues have reviewed some of the potential benefits and drawbacks of intermittent preventive antimalarial treatment in children (IPTc).
Bojang, Kalifa   +5 more
core   +1 more source

Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability [PDF]

open access: yes, 2013
Background: The need for new malaria surveillance tools and strategies is critical, given improved global malaria control and regional elimination efforts.
Abdullah S Ali   +26 more
core   +2 more sources

Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies

open access: yesApplied Research, Volume 4, Issue 5, October 2025.
Schematic representation of orally administered antimalarial–oligochitosan conjugates. The mucoadhesive properties of oligochitosan facilitate enhanced drug absorption across the intestinal epithelium (Image created in BioRender.com & Microsoft 365 PowerPoint).
William Matshe   +9 more
wiley   +1 more source

Exploration of in Vivo Efficacy of Artemether-Lumefantrine Against Uncomplicated Plasmodium Falciparum Malaria in Under Fives in Tabora Region, Tanzania. [PDF]

open access: yes, 2013
Tanzania adopted artemether-lumefantrine (AL) as first-line drug for uncomplicated malaria in 2006. Recently, there was an anecdotal report on high malaria recurrence rate following AL treatment in in the (urban and peri-urban), western part of Tanzania.
Hulser, Ruth   +5 more
core   +3 more sources

Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates [PDF]

open access: hybrid, 2021
Flore Nardella   +7 more
openalex   +1 more source

Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

open access: yesDiabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv   +7 more
wiley   +1 more source

Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐Causing Malaria: A Computational Approach

open access: yesHealth Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study
Amma Aboagyewa Larbi   +6 more
wiley   +1 more source

Phytochemical Screening and in vivo antioxidant activity of Ethanolic extract of caesalpinia bondus (L.) Roxb [PDF]

open access: yes, 2012
Phytochemical screening, antioxidant activity in vivo and lipid peroxidation of 75 % ethanolic extract of young twigs and leaves of Caesalpinia bonduc were carried out by chemical test, and assessment of catalase and peroxidase activities and lipid ...
Akindahunsi , A. A   +4 more
core   +1 more source

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