Results 81 to 90 of about 10,947 (204)

Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

Malaria Journal, 2010
The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.
Twu Olivia, Sa Juliana M
doaj   +1 more source

Immunoinformatics‐Based Multi‐Epitope Vaccine Design Against P. falciparum‐Causing Malaria: A Computational Approach

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study
Amma Aboagyewa Larbi, Caleb Mensah, Rebecca Korankye, Andrew Appiah Darkwah, Esther Boakye Agyemang, Isaac Yao Ayikpah, Alexander Kwarteng   +6 more
wiley   +1 more source

Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali

Malaria Journal, 2009
Background To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.
Wele Mamadou, Dembele Demba, Kone Aminatou, Dama Souleymane, Ouologuem Dinkorma, Fofana Bakary, Sagara Issaka, Maiga Hamma, Beavogui Abdoul H, Djimde Abdoulaye A, Tekete Mamadou, Dicko Alassane, Doumbo Ogobara K   +12 more
doaj   +1 more source

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster‐Randomised Trial

Maternal &Child Nutrition, Volume 21, Issue 4, October 2025.
Globally nearly 40% of children under 5 years old are anaemic, which affects their ability to grow and develop. A cluster randomised trial was conducted in 60 communities in Southern Mali to evaluate the added impact of home fortification with micronutrient powders, delivered alongside seasonal malaria chemoprevention, on anaemia, malaria infection ...
Niélé H. Diarra, Yahia Dicko, Natalie Roschnik, Modibo Bamadio, Michael Boivin, Yvonne Griffiths, Rebecca Jones, Sham Lal, Helen Moestue, Hamidou Niangaly, Lauren Pisani, Renion Saye, Kalifa Sidibe, Karla Smuts, Nia‐An Philippe Thera, Josselin Thuilliez, Hans Verhoef, Moussa Sacko, Siân E. Clarke   +18 more
wiley   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended in the ...
R. Grais, I. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, C. Langendorf, A. Amambua-Ngwa, U. d’Alessandro, P. Guérin, T. Fandeur, C. Sibley   +10 more
semanticscholar   +1 more source

Concentration–Response Analysis of the Combination of Pyronaridine and Piperaquine on Corrected QT Interval From a Randomized, Double‐Blind, Placebo‐Controlled Study in Healthy Adults of African Sub‐Saharan Origin

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT A novel oral combination of the long‐acting antimalarials pyronaridine (PYR) and piperaquine (PQP) has potential for malaria chemoprevention. This single‐center randomized, double‐blind, placebo‐controlled study assessed the effects of PYR and PQP alone and when co‐administered on Fridericia‐corrected QT interval (QTcF).
Mathieu Felices, Isabelle Borghini‐Fuhrer, Nada Abla, Stephan Chalon   +3 more
wiley   +1 more source

Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial

Lancet. Infectious Diseases (Print), 2022
T. Peto, R. Tripura, J. Callery, D. Lek, H. Nghia, C. Nguon, Nguyen Thi Huyen Thuong, Rob W. van der Pluijm, N. Dung, Meas Sokha, Vo Van Luong, L. T. Long, Yok Sovann, Jureeporn Duanguppama, Naomi Waithira, R. Hoglund, Palang Chotsiri, N. H. Chau, A. Ruecker, C. Amaratunga, M. Dhorda, Olivo Miotto, R. Maude, H. Rekol, K. Chotivanich, J. Tarning, L. von Seidlein, M. Imwong, M. Mukaka, N. Day, T. Hien, N. White, A. Dondorp   +32 more
semanticscholar   +1 more source

From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns

Scientific Reports, 2017
Drug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent.
Sebastian Salentin, Melissa F. Adasme, J. Heinrich, V. J. Haupt, Simone Daminelli, Yixin Zhang, M. Schroeder   +6 more
semanticscholar   +1 more source

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

Antimicrobial Agents and Chemotherapy, 2018
Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic. However, pediatric doses are largely based on a linear extrapolation from adult doses.
A. Ali, M. Penny, Thomas A. Smith, L. Workman, P. Sasi, G. Adjei, F. Aweeka, J. Kiechel, V. Jullien, M. Rijken, R. McGready, Julia Mwesigwa, K. Kristensen, K. Stepniewska, J. Tarning, K. Barnes, P. Denti, Achille Adama Adicat Agnés Alphonse Anna Arnaud Aung Pyae Massougbodji Gansané Adeothy Aubouy Ouedraogo Anne   +17 more
semanticscholar   +1 more source