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Dissolution Mechanisms of Amorphous Solid Dispersions
2023The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of significant importance for establishing a therapeutic effect in patients. However, the current pharmaceutical landscape is abundant in poorly soluble drugs that require solubility enhancing techniques to enable their administration. A promising technique, with
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Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions
Current Pharmaceutical Design, 2014Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and ...
Chow, Albert H.L. +5 more
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Release Mechanisms of Amorphous Solid Dispersions
2022As the pharmaceutical industry moves towards molecular obesity with the use of high throughput screening for identification of promising candidates, the low aqueous solubilities of new chemical entities pose significant challenges to achieving adequate oral absorption and bioavailability.
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Overview of Amorphous Solid Dispersion Technologies
2014Successful development of amorphous solid dispersion formulations depends on three primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the processing technology. Polymer provides the fundamental framework for stabilizing the amorphous form and the process supplies the energy required to transform the system into an ...
Harpreet Sandhu +3 more
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Diffusivity of amorphous drug in solid dispersion
Journal of Thermal Analysis and Calorimetry, 2013Filmy solid dispersion of terfenadine (TFD), fenofibrate (FFB), and carbamazepine (CBZ) and methacrylic acid methyl methacrylate copolymer (Eudragit®) was prepared by evaporating their solution. Raman and IR measurements for the filmy samples were performed.
Etsuo Yonemochi +3 more
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Anomalous transit-time dispersion in amorphous solids
Physical Review B, 1975Measurements of the transient photocurrent $I(t)$ in an increasing number of inorganic and organic amorphous materials display anomalous transport properties. The long tail of $I(t)$ indicates a dispersion of carrier transit times. However, the shape invariance of $I(t)$ to electric field and sample thickness (designated as universality for the classes
Harvey Scher, Elliott W. Montroll
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Characterization of amorphous solid dispersions: An update
Journal of Drug Delivery Science and Technology, 2019Abstract Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have complicated physicochemical properties due to the various formulations and processes used to produce them. These properties influence their physical stability, so it
Xiangyu Ma, Robert O. Williams
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Physical Stability Studies of Miscible Amorphous Solid Dispersions
Journal of Pharmaceutical Sciences, 2010Physical stability of 12 amorphous solid dispersions was evaluated over 9-22 months under ambient conditions using X-ray powder diffraction. The nine dispersions initially characterized as miscible drug-polymer systems all remained X-ray amorphous for the duration of their respective studies.
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Theoretical Considerations in Developing Amorphous Solid Dispersions
2014Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in ...
Laitinen, Riikka +6 more
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Orodispersible films based on amorphous solid dispersions of tetrabenazine
International Journal of Pharmaceutics, 2017In this work, the formation and stability of amorphous solid dispersions (SDs) as orodispersible films (ODF) were investigated using tetrabenazine (TBZ) as a poorly water soluble drug. The influence of polymer nature and pH-modifier incorporation to form and maintain SDs was investigated. TBZ-loaded ODF were formulated using 4 different polymers (HPMC,
Senta-Loys, Zoé +4 more
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