Updated safety evaluation of the food enzyme AMP deaminase from the non‐genetically modified Streptomyces murinus strain AE‐DNTS [PDF]
EFSA JournalThe food enzyme AMP deaminase (AMP aminohydrolase; EC 3.5.4.6) is produced with the non‐genetically modified Streptomyces murinus strain AE‐DNTS by Amano Enzyme Inc. In a previous evaluation, the Panel could not conclude on the safety of this food enzyme
EFSA Panel on Food Enzymes (FEZ) +14 more
doaj +3 more sources
AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism. [PDF]
PLoS ONE, 2013 A hypometabolic state can be induced in mice by 5'-AMP administration. Previously we proposed that an underlying mechanism for this hypometabolism is linked to reduced erythrocyte oxygen transport function due to 5'-AMP uptake altering the cellular ...
Isadora Susan Daniels +4 more
doaj +5 more sources
Safety evaluation of the food enzyme AMP deaminase from the non‐genetically modified Streptomyces murinus strain AE‐DNTS [PDF]
EFSA Journal, 2023 The food enzyme AMP deaminase (AMP aminohydrolase; EC 3.5.4.6) is produced with the non‐genetically modified Streptomyces murinus strain AE‐DNTS by Amano Enzyme Inc. The food enzyme is free from viable cells. It is intended to be used in yeast processing
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) +23 more
doaj +2 more sources
Role of the HPRG Component of Striated Muscle AMP Deaminase in the Stability and Cellular Behaviour of the Enzyme [PDF]
Biomolecules, 2018 Multiple muscle-specific isoforms of the Zn2+ metalloenzyme AMP deaminase (AMPD) have been identified based on their biochemical and genetic differences.
Francesca Ronca, Antonio Raggi
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Effect of isolated AMP deaminase deficiency on skeletal muscle function [PDF]
Molecular Genetics and Metabolism Reports, 2014 Mutation of the AMP deaminase 1 (AMPD1) gene, the predominate AMPD gene expressed in skeletal muscle, is one of the most common inherited defects in the Caucasian population; 2–3% of individuals in this ethnic group are homozygous for defects in the ...
Jidong Cheng +15 more
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Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts [PDF]
Physiological Reports, 2023 Systemic branched‐chain amino acid (BCAA) metabolism is dysregulated in cardiometabolic diseases. We previously demonstrated that upregulated AMP deaminase 3 (AMPD3) impairs cardiac energetics in a rat model of obese type 2 diabetes, Otsuka Long‐Evans ...
Toshifumi Ogawa +14 more
doaj +2 more sources
Muscle AMP deaminase activity was lower in Neandertals than in modern humans [PDF]
Nature CommunicationsThe enzyme AMPD1 is expressed in skeletal muscle and is involved in ATP production. All available Neandertal genomes carry a lysine-to-isoleucine substitution at position 287 in AMPD1.
Dominik Macak +6 more
doaj +2 more sources
Safety evaluation of the food enzyme AMP deaminase from the non‐genetically modified Aspergillus pallidofulvus strain AE‐DN [PDF]
EFSA JournalThe food enzyme AMP deaminase (AMP aminohydrolase; EC 3.5.4.6) is produced with the non‐genetically modified Aspergillus pallidofulvus strain AE‐DN by Amano Enzyme Inc. The food enzyme was free from viable cells of the production organism. It is intended
EFSA Panel on Food Enzymes (FEZ) +17 more
doaj +2 more sources
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. [PDF]
PLoS ONE, 2012 Fatty liver (hepatic steatosis) is associated with nucleotide turnover, loss of ATP and generation of adenosine monophosphate (AMP). It is well known that in fatty liver, activity of the AMP-activated kinase (AMPK) is reduced and that its stimulation can
Miguel A Lanaspa +13 more
doaj +2 more sources
Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel. [PDF]
PLoS ONE, 2015 Hibernating animals develop fatty liver when active in summertime and undergo a switch to a fat oxidation state in the winter. We hypothesized that this switch might be determined by AMP and the dominance of opposing effects: metabolism through AMP ...
Miguel A Lanaspa +17 more
doaj +2 more sources