Results 21 to 30 of about 11,264 (186)

The metabolic engineering of Escherichia coli for the high-yield production of hypoxanthine [PDF]

Microbial Cell Factories
Background Hypoxanthine, prevalent in animals and plants, is used in the production of food additives, nucleoside antiviral drugs, and disease diagnosis.
Siyu Zhao, Tangen Shi, Liangwen Li, Zhichao Chen, Changgeng Li, Zichen Yu, Pengjie Sun, Qingyang Xu   +7 more
doaj   +2 more sources

Metabolic Aspects of Adenosine Functions in the Brain

Frontiers in Pharmacology, 2021
Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil, Mercedes Garcia-Gil, Marcella Camici, Simone Allegrini, Rossana Pesi, Maria Grazia Tozzi   +5 more
doaj   +1 more source

Two Rare Cases of Long Surviving Riboflavin Transporter Deficiency with Co-Existing Adenosine Monophosphate Deaminase (AMP) Deficiency

Brain Sciences, 2022
(1) Background: Riboflavin transporter deficiency (RTD), formerly known as Brown–Vialetto–Van Laere syndrome, is a rare condition that causes a progressive neurological syndrome in early life with features of auditory and optic neuropathy, weakness of ...
Lin Zhang, Dominic Thyagarajan
doaj   +1 more source

Structural basis for the substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase. [PDF]

J Biol Chem
Kaur G, Horton JR, Tzertzinis G, Zhou J, Schildkraut I, Cheng X.   +5 more
europepmc   +3 more sources

Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients

مجلة بغداد للعلوم, 2010
Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy.
Baghdad Science Journal
doaj   +1 more source

5′-Nucleotidase and AMP-deaminase activities of liver postnuclear fraction and blood serum of rats with transplanted Guerin’s carcinoma

Біологічні студії, 2009
The dynamics of the levels of 5′-nucleotidase and AMP-deaminase activity in postnuclear fraction of rat liver and serum was studied during transplanted Guerin’s carcinoma growth in rats.
H. P. Kopylchuk, I. M. Buchkovska, O. M. Voloschuk   +2 more
doaj   +1 more source

Regulation of AMP Deaminase by Phosphoinositides [PDF]

Journal of Biological Chemistry, 1999
AMP deaminase (AMPD) converts AMP to IMP and is a diverse and highly regulated enzyme that is a key component of the adenylate catabolic pathway. In this report, we identify the high affinity interaction between AMPD and phosphoinositides as a mechanism for regulation of this enzyme.
B, Sims, D K, Mahnke-Zizelman, A A, Profit, G D, Prestwich, R L, Sabina, A B, Theibert   +5 more
openaire   +2 more sources

L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues

The Scientific World Journal, 2012
L-arginine is conditionally essetcial amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence.
G. Kocic, J. Nikolic, T. Jevtovic-Stoimenov, D. Sokolovic, H. Kocic, T. Cvetkovic, D. Pavlovic, A. Cencic, D. Stojanovic   +8 more
doaj   +1 more source

Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2020
The loss of cognitive function in Alzheimer’s disease is pathologically linked with neurofibrillary tangles, amyloid deposition, and loss of neuronal communication.
Richard J. Johnson, Fernando Gomez-Pinilla, Maria Nagel, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Laura G. Sanchez-Lozada, Dean R. Tolan, Miguel A. Lanaspa   +7 more
doaj   +1 more source

Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease

iScience, 2023
Summary: Sarcopenia is a common and devastating condition in patients with chronic kidney disease (CKD). Here, we provide evidence that the kidney-muscle crosstalk in sarcopenia is mediated by reduced insulin sensitivity and the activation of the muscle ...
Ana Andres-Hernando, Christina Cicerchi, Gabriela E. Garcia, David J. Orlicky, Peter Stenvinkel, Richard J. Johnson, Miguel A. Lanaspa   +6 more
doaj   +1 more source