Results 41 to 50 of about 11,264 (186)
MedComm, Volume 6, Issue 12, December 2025.The therapeutic potential of ataluren for NF1 nonsense mutations was assessed by a comprehensive evaluation of the RAS/MEK/ERK pathway activity in 22 NF1NS/+ patient‐derived fibroblasts. The whole‐transcriptomic profiles between ataluren responders and nonresponders, and further analysis and validation revealed novel biomarkers, AMPD3 and TGFBR3, for ...
Soyoung Kim +8 more
wiley +1 more source
PLoS ONE, 2012 Medulloblastoma (MB) is the most common malignant brain tumor in children and occurs mainly in the cerebellum. Important intracellular signaling molecules, such those present in the Sonic Hedgehog and Wnt pathways, are involved in its development and can
Angélica Regina Cappellari +9 more
doaj +1 more source
Cells, 2020 Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside’s putative relevance in wound healing, dermal fibrosis, and myofascial pain, we ...
Carina Herman-de-Sousa +9 more
doaj +1 more source
Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations
MedComm, Volume 6, Issue 12, December 2025.Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong +8 more
wiley +1 more source
Fast-tracking antibody maturation using a B cell-based display system
mAbs, 2022 Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly ...
Hitomi Masuda +9 more
doaj +1 more source
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies
MedComm – Oncology, Volume 4, Issue 4, December 2025.Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.ABSTRACT Background Mounting evidence indicates that Type 2 diabetes mellitus (T2DM) is a public health challenge globally, and its occurrence is anticipated to surge in the forthcoming years. Dipeptidyl peptidase‐4 (DPP‐4) serves as a target for its treatment, with its inhibitors effectively preserving the levels of glucose‐dependent insulinotropic ...
Chinyere Aloke +4 more
wiley +1 more source
Mediators of Inflammation, 2015 AMP dephosphorylation via ecto-5′-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A2A receptors (A2ARs), is a potent modulator of neuromuscular and immunological responses.
Laura Oliveira +7 more
doaj +1 more source
European Journal of Histochemistry, 2011 Histidine-rich glycoprotein (HRG) is synthesized by liver and is present at relatively high concentration in the plasma of vertebrates. We have previously described the association of a HRG-like molecule to purified rabbit skeletal muscle AMP deaminase ...
A.R.M. Sabbatini +7 more
doaj +1 more source
Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p
JHEP Reports, 2021 Background & Aims: Immune-mediated induction of cytidine deaminase APOBEC3B (A3B) expression leads to HBV covalently closed circular DNA (cccDNA) decay.
Suzanne Faure-Dupuy +29 more
doaj +1 more source