Results 171 to 180 of about 128,807 (272)

The Effect of the Anticonvulsant Topiramate on Acetylcholine‐Induced Calcium Signals is Linked to Sirt‐1 Activity

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
This work provides a potential new link between the anticonvulsive Topiramate, the deacetylase Sirt‐1 and the cholinergic signalling, suggesting that Topiramate may modulate cholinergic pathways in a Sirt‐1 depended manner. ABSTRACT Although some forms of epilepsy directly result from mutations in nicotinic acetylcholine receptors, none of the ...
Marie‐Luise Kümmel
wiley   +1 more source

Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes. [PDF]

Clin Rev Allergy Immunol
Clanchy FIL, Williams RO, Stone TW.
europepmc   +1 more source

Unveiling the Molecular Mechanism of Intestinal Metabolite para‐Cresol in Modulating Neuroinflammation and Synaptic Dysfunction: Implications for Autism Spectrum Disorder

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Here we investigated the effect of p‐Cresol on different brain‐cell types to speculate on their specific contribution to autism spectrum disorder (ASD) synaptic dysfunctions. Our in vitro data show that p‐Cresol impairs dendritic arborization and length, disrupts the excitatory/inhibitory balance, and induces glial activation and inflammatory responses.
Wenjie Liao, Kristy Antonioni, Federica Silvestri, Monica Piemontese, Martina Bodria, Eleonora Daini, Antonio M. Persico, Michele Zoli, Andreas M. Grabrucker, Antonietta Vilella   +9 more
wiley   +1 more source

6,7-Dihalo-Benzothiadiazines as Potent and Selective AMPA Receptor Modulators for Cognitive Enhancement and Neuroprotection. [PDF]

ACS Med Chem Lett
Li Y, Yuan H, Liang SH.
europepmc   +1 more source

The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse. [PDF]

, 2007
Erazo Fischer, E.
core   +1 more source

N,N‐Dimethyltryptamine (DMT) Acutely Exposed to Mouse Ventral Tegmental Area Ih‐Negative Neurons Alters the Firing Rate and Conductance in a Sex‐Dependent Manner

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Depression and substance use disorder are difficult to treat, prompting interest in psychedelics like DMT, though its neural mechanisms remain unclear. This ex vivo study examined acute DMT effects on electrophysiology in male and female Ih‐negative neurons of the mouse ventral tegmental area (VTA). Low‐dose DMT (500 nM) had no effect, whereas a higher
Jannik Nicklas Eliasen, Amir Rezagholizadeh, Helene Påbøl Jacobsen, Kristi A. Kohlmeier   +3 more
wiley   +1 more source

Glutamatergic Enhancement Using As-Needed Dextromethorphan and Piracetam in a Stimulant-Partially Responsive Adult With ADHD: A Single-Case Report. [PDF]

Cureus
Cheung N.
europepmc   +1 more source

The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics

Psychiatry and Clinical Neurosciences, Volume 80, Issue 5, Page 367-373, May 2026.
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, Volume 604, Issue 10, Page 3934-3963, 15 May 2026.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Modulation of glutamate metabolism in Niemann-pick disease type C1 mice. [PDF]

Mol Genet Metab Rep
Cougnoux A, Alvarez CS, Maria AG, Hernandez E, Cawley NX, Davidson CD, Porter FD.   +6 more
europepmc   +1 more source