Results 241 to 250 of about 88,309 (267)

Sensitivity of AMPA receptors to pentobarbital

European Journal of Pharmacology: Molecular Pharmacology, 1994
The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
Lu-Yang Wang, Franco A. Taverna, Billie-Rose Cameron, David L. Hampson, John F. MacDonald   +4 more
openaire   +3 more sources

AMPA receptors and perampanel behind selected epilepsies: current evidence and future perspectives

Expert Opinion on Pharmacotherapy, 2017
Introduction: The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered:
C. Di Bonaventura, A. Labate, M. Maschio, S. Meletti, E. Russo   +4 more
semanticscholar   +1 more source

Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition

Science, 1991
NMDA (N-methyl-D-aspartate) receptors and non-NMDA receptors represent the two major classes of ion channel-linked glutamate receptors. Unlike the NMDA receptor channels, non-NMDA receptor channels have usually been thought to conduct monovalent cations ...
M. Hollmann, M. Hartley, S. Heinemann
semanticscholar   +1 more source

The AMPA receptors of auditory neurons

Hearing Research, 2000
The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
openaire   +3 more sources

A family of AMPA-selective glutamate receptors.

Science, 1990
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library.
K. Keinänen, W. Wisden, B. Sommer, P. Werner, A. Herb, T. Verdoorn, B. Sakmann, P. Seeburg   +7 more
semanticscholar   +1 more source

In Search of Novel AMPA Potentiators

Recent Patents on CNS Drug Discovery, 2006
Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation.
Pierre Francotte, Stéphane Counerotte, Pierre Fraikin, Bernard Pirotte, Pascal De Tullio, Eric Goffin   +5 more
openaire   +3 more sources

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

Journal of Medicinal Chemistry, 2016
Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the ...
K. Gardinier, D. Gernert, Warren J. Porter, J. Reel, P. Ornstein, P. Spinazze, F. Craig Stevens, P. Hahn, S. Hollinshead, D. Mayhugh, J. Schkeryantz, A. Khilevich, Ó. de Frutos, S. Gleason, Akihiko S. Kato, D. Luffer-Atlas, Prashant V. Desai, S. Swanson, Kevin D. Burris, Chunjin Ding, Beverly A. Heinz, A. Need, V. Barth, Gregory A. Stephenson, B. Diseroad, Tim A. Woods, Hong Yu, D. Bredt, J. Witkin   +28 more
semanticscholar   +1 more source

Stargazin and the AMPA receptor

Science, 2016
Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
openaire   +2 more sources

Glyphosate and Its Degradation Product AMPA Occur Frequently and Widely in U.S. Soils, Surface Water, Groundwater, and Precipitation

, 2014
Glyphosate use in the United States increased from less than 5,000 to more than 80,000 metric tons/yr between 1987 and 2007. Glyphosate is popular due to its ease of use on soybean, cotton, and corn crops that are genetically modified to tolerate it ...
W. Battaglin, M. Meyer, K. Kuivila, Julie E. Dietze   +3 more
semanticscholar   +1 more source

AMPA Receptor Trafficking and GluR1

Science, 2005
In their Research Article “Postsynaptic receptor trafficking underlying a form of associative learning” (1 Apr., p. 83), S. Rumpel et al. draw the important conclusions that “encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking” and that “synaptic incorporation of AMPARs is necessary for learning.” The key experiment ...
openaire   +3 more sources