Results 271 to 280 of about 140,198 (327)

The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity. [PDF]

Nat Commun
Valencia T, Yen LY, Berman C, Vincent T, Davis S, Varrone F, Huang J, Mastroianni J, Carlson M, Owen T, Kamel A, Drygin D, Kinberger GA, Gangwar SP, Yelshanskaya MV, Ridley J, Kirby R, Alvarez J, Lakhia R, Patel V, Sobolevsky AI, Lee EC.   +21 more
europepmc   +1 more source

O-GlcNAc transferase couples nutrient availability to synaptic plasticity in paraventricular neurons to regulate satiety. [PDF]

J Biol Chem
Pérez-Del-Pozo M, Bhattacharjee M, Tripathi A, Boafo T, Galizia S, Medini P, Druzin M, Lagerlöf O.   +7 more
europepmc   +1 more source

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AMPA Receptor Antagonists

Current Medicinal Chemistry, 2001
AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury.
S S, Nikam, B E, Kornberg
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Competitive AMPA Receptor Antagonists

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA, COLOTTA, VITTORIA, VARANO, FLAVIA   +2 more
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Phosphonate quinoxalinedione AMPA antagonists

Restorative Neurology and Neuroscience, 2000
In the Western world, over 350,000 deaths and $30 billion in medical costs are attributed annually to stroke. Head and spinal cord trauma cause an estimated 250,000 deaths annually and result in medical costs of $15 billion. Although stroke and head/spinal cord trauma are leading causes of disability and death in humans, no adequate neuroprotective ...
Lechoslaw, Turski, Herbert H., Schneider, Roland, Neuhaus, Fiona, McDonald, Graham H., Jones, Boel, Löfberg, Hermann, Schweinfurth, Andreas, Huth, Martin, Krüger, Eckhard, Ottow   +9 more
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2,3-Benzodiazepine AMPA Antagonists

Restorative Neurology and Neuroscience, 1998
The 2,3-benzodiazepine GYKI 52466 (1-(4-aminophenyl)-4 methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine) and its analogues represent a family of selective AMPA antagonists. They modulate AMPA channel functions through an allosteric site on the receptor, which is probably different from the ones involved in the actions of cyclothiazide and aniracetam ...
I, Tarnawa, E S, Vize
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Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins

Neuroscience, 2009
The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
C, Sager, D, Tapken, S, Kott, M, Hollmann   +3 more
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AMPA receptor antagonists

Expert Opinion on Therapeutic Patents, 1999
It is now generally recognised that glutamate is the major excitatory neurotransmitter in vertebrate central nervous system (CNS). It acts at ionotropic and metabotropic receptors which appear to play important roles in all aspects of CNS functions. The ionotropic receptors, which are involved in fast synaptic transmission, belong to three subtypes ...
CHIMIRRI, Alba, GITTO, Rosaria, ZAPPALA', Maria   +2 more
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