Results 271 to 280 of about 89,264 (312)
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Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding

European Journal of Pharmacology, 1997
AMPA receptors can be labeled using the agonist radioligands [3H](R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ([3H](R,S)-AMPA), [3H](S)-AMPA or [3H](S)-5-fluorowillardiine. In the presence of KSCN, [3H](R,S)-AMPA and [3H](S)-AMPA bind to a single population of sites in rat brain membranes, whereas [3H](S)-5-fluorowillardiine binds ...
Stephen A. Espitia, Jon E. Hawkinson
openaire   +3 more sources

AMPA Receptor Antagonists

Current Medicinal Chemistry, 2001
AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury.
Sham Shridhar Nikam   +1 more
openaire   +2 more sources

RNA aptamers for AMPA receptors

Neuropharmacology, 2021
RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors ...
Zhen Huang, Li Niu
openaire   +3 more sources

AMPA receptor antagonists

Expert Opinion on Therapeutic Patents, 1999
It is now generally recognised that glutamate is the major excitatory neurotransmitter in vertebrate central nervous system (CNS). It acts at ionotropic and metabotropic receptors which appear to play important roles in all aspects of CNS functions. The ionotropic receptors, which are involved in fast synaptic transmission, belong to three subtypes ...
CHIMIRRI, Alba   +2 more
openaire   +3 more sources

Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.

Science, 2000
To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons.
Y. Hayashi   +5 more
semanticscholar   +1 more source

Competitive AMPA Receptor Antagonists

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA   +2 more
openaire   +4 more sources

Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking.

Annual Review of Physiology, 2016
For more than 20 years, we have known that Ca(2+)/calmodulin-dependent protein kinase (CaMKII) activation is both necessary and sufficient for the induction of long-term potentiation (LTP). During this time, tremendous effort has been spent in attempting
B. Herring, R. Nicoll
semanticscholar   +1 more source

Glyphosate and AMPA of agricultural soil, surface water, groundwater and sediments in areas prevalent with chronic kidney disease of unknown etiology, Sri Lanka

Journal of Environmental Science and Health. Part B - Pesticides, Food Contaminants, and Agricultural Wastes, 2018
Glyphosate, which is commercially available as RoundupĀ®, was the widely used herbicide in Sri Lanka until 2015 and is suspected to be one of the causal factors for Chronic Kidney Disease of unknown etiology (CKDu).
S. Gunarathna   +4 more
semanticscholar   +1 more source

New AMPA antagonists in epilepsy

Expert Opinion on Investigational Drugs, 2012
Epilepsy is a common neurological disorder; however, its therapy is not satisfactory because a large number of patients suffer from refractory seizures and/or has a low quality of life due to antiepileptic drug (AED) side effects. Glutamate is the major excitatory neurotransmitter in the brain, AMPA receptors (AMPARs) represent a validated target for ...
Russo E   +4 more
openaire   +3 more sources

Neurotrophic effects of AMPA

The Cerebellum, 2004
AMPA-type glutamate receptors may transduce both neurotoxic and neurotrophic signals, basically depending on receptor subunit composition and on the extent of receptor activation. While a great deal of data are available on the mechanisms underlying the neurotoxic effects induced by AMPA receptor stimulation, much less is known about the molecular ...
openaire   +4 more sources

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