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Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins
Neuroscience, 2009The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
Michael Hollmann+3 more
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AMPA Receptor Cycling in the Synapse
Science's STKE, 2004Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and,
Anis Contractor, Stephen F. Heinemann
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Inhibitors of AMPA and Kainate Receptors
Current Medicinal Chemistry, 2001The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
P. Krogsgaard-Larsen+2 more
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Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.
Science, 1999To monitor changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor distribution in living neurons, the AMPA receptor subunit GluR1 was tagged with green fluorescent protein (GFP).
Song-Hai Shi+6 more
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Science Signaling, 2009
A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered.
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A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered.
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Sensitivity of AMPA receptors to pentobarbital
European Journal of Pharmacology: Molecular Pharmacology, 1994The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
Lu-Yang Wang+4 more
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Stargazin and the AMPA receptor
Science, 2016Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
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A family of AMPA-selective glutamate receptors.
Science, 1990Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library.
K. Keinänen+7 more
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The AMPA receptors of auditory neurons
Hearing Research, 2000The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
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In Search of Novel AMPA Potentiators
Recent Patents on CNS Drug Discovery, 2006Glutamate is the major excitatory neurotransmitter in the brain. Amongst ionotropic receptors responding to glutamate, the AMPA subtype has been considered as essential for the fast excitatory neurotransmission in the central nervous system and the expression and maintenance of long-term potentiation.
Pierre Francotte+5 more
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