Results 71 to 80 of about 70,772 (270)

Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors

, 2005
Genetic perturbations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory.
Shimshek Derya R, Mack Volker, Derya R Shimshek, Peter H Seeburg, Sprengel, Rolf, Bus, T, Mihaljevic Andre, Bus, T., Sprengel, R, Kim Jinhyun, Schaefer, AT, Mihaljevic, A, Thorsten Bus (71683), Peter H Seeburg (71687), Shimshek, DR, Rolf Sprengel (71688), Schaefer, Andreas T., Seeburg, P., Jinhyun Kim, Andre Mihaljevic, Volker Mack (71686), Mihaljevic, André, Shimshek, Derya R., Derya R Shimshek (71682), Bus, Thorsten, Seeburg, Peter H., Rolf Sprengel, Kim, Jinhyun, Mack, V, Schaefer, A., Bus Thorsten, Schaefer Andreas T, Jinhyun Kim (71684), Kim, J, Seeburg Peter H, Seeburg, PH, Kim, J., Thorsten Bus, Andreas T Schaefer, Shimshek, D., Mack, Volker, Sprengel Rolf, Mack, V., Andre Mihaljevic (71685), Volker Mack, Mihaljevic, A., Sprengel, R., Andreas T Schaefer (71689)   +47 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain

, 2003
The ligand-binding domains of AMPA receptor subunits carry two conserved N-glycosylation sites. In order to gain insight into the functional role of the corresponding N-glycans, we examined how the elimination of glycosylation at these sites (N407 and ...
Sarah K. Coleman, Jean Rossier, Michael Pasternack, Jean-Pierre LeCaer, Kari Keinänen, Arja Pasternack, James Féthière, Dean R. Madden   +7 more
core   +1 more source

A Study on Attitude of Pre-service Secondary Teachers Towards Human Rights Education and Peace Education

Dera Natung Government College Research Journal, 2016
The investigators conducted a study to know the attitude towards Human Rights Edu- cation and Peace Education of pre-service secondary teachers of Department of Education, Rajiv Gandhi University, Hills College of Teacher Education and Donyi-Polo B.Ed ...
Sony Dupak, Tage Ampa
doaj   +1 more source

The role of IgM anti‐acetylated protein antibodies and B cells in the origin of anti‐modified protein autoimmunity in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur HLO, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E.M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba, Annika A. de Goede, Joost. C. van Mechelen, Laura G. J. M. Borghans, Liam van der Aa, Erik Olofsen, Maria J. Juachon, Robert J. Doll, Amy Gillespie, Catherine J. Harmer, Gabriël E. Jacobs, Jules A. A. C. Heuberger   +11 more
wiley   +1 more source

Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications

Arthritis Research & Therapy, 2021
Background Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetylated proteins.
M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes, D. van der Woude   +9 more
doaj   +1 more source

Dysregulation of AMPA Receptor Trafficking and Intracellular Vesicular Sorting in the Prefrontal Cortex of Dopamine Transporter Knock-Out Rats

Biomolecules, 2023
Dopamine (DA) and glutamate interact, influencing neural excitability and promoting synaptic plasticity. However, little is known regarding the molecular mechanisms underlying this crosstalk.
Giorgia Targa, Francesca Mottarlini, Beatrice Rizzi, Damiana Leo, Lucia Caffino, Fabio Fumagalli   +5 more
doaj   +1 more source

Allosteric competition and inhibition in AMPA receptors

Nature Structural & Molecular Biology, 2023
Abstract Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through
W. Dylan Hale, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman, Albert Y. Lau, Richard L. Huganir, Edward C. Twomey   +6 more
openaire   +3 more sources

The N-terminal domain modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor desensitization

, 2014
AMPA receptors are tetrameric glutamate-gated ion channels that mediate fast synaptic neurotransmission in mammalian brain. Their subunits contain a two-lobed N-terminal domain (NTD) that comprises over 40% of the mature polypeptide.
Coleman, S.K., Semenov, A., Keinänen, K., Moykkynen, T.   +3 more
core   +1 more source