Results 91 to 100 of about 2,417 (187)

Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model

Neuroscience Research
NMDA and AMPA receptors are co-localized at most glutamatergic synapses, where their numbers and distribution undergo dynamic changes. Glutamate binds to both the NMDA and AMPA receptors.
Qingchen Guo
doaj   +1 more source

AMPA [PDF]

Air Medical Journal, 2003
openaire   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Exposure of Farmers and Spouses to Glyphosate in Morocco: Urinary Levels and Predictors of Exposure

Toxics
Levels of glyphosate and their metabolite AMPA were measured in urine of farmers and their spouses that lived in intensively farmed area in Morocco.
Imane Berni, Aziza Menouni, Matteo Creta, Kaoutar Chbihi, Hala Chetouani, Said Abou-Said, Lode Godderis, Samir El Jaafari, Radu-Corneliu Duca   +8 more
doaj   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Ion binding sites and intermediate domain closure induced by D‐serine in the GluD1 ligand‐binding domain

The FEBS Journal, EarlyView.
GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen, Emma Grosvald Pedersen, Dilip Narayanan, Karla A. Frydenvang, Jette Sandholm Kastrup   +4 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

The role of hydration in the removal of glyphosate (GLY) and aminomethylphosphonic acid (AMPA) by nanofiltration membranes

Nature Communications
Nanofiltration can remove glyphosate (GLY) and aminomethylphosphonic acid (AMPA) from water via steric, Donnan, and dielectric exclusions, although the significance of dielectric exclusion resulting from hydration has not been elucidated.
Phuong B. Trinh, Minh N. Nguyen, Zdenek Futera, Babak Minofar, Marco Personeni, Poul B. Petersen, Andrea I. Schäfer   +6 more
doaj   +1 more source

Extraction, Detection, and Quantification Methods for Analyzing Glyphosate and AMPA in Foods: Challenges and Opportunities

Applied Sciences
Glyphosate (GLYP) is an effective and low-cost broad-spectrum herbicide. However, this herbicide and its primary degradation product, aminomethylphosphonic acid (AMPA), have been linked with adverse human health effects.
Andony David González-Cruz, Luis Miguel Anaya-Esparza, Ignacio Valenzuela-Chavira, Fernando Martínez-Esquivias, José Martín Ruvalcaba-Gómez, Jorge Manuel Silva-Jara, Carlos Arnulfo Velázquez-Carriles, Iván Balderas-León, Ramón I. Arteaga-Garibay, Zuamí Villagrán   +9 more
doaj   +1 more source

Occurrence and Levels of Glyphosate, Chlorate and Perchlorate in Irish Drinking Water: A Pilot Study

Water and Environment Journal, EarlyView.
ABSTRACT Safe drinking water is a crucial component of public health. Pesticides and disinfection byproducts are known pollutants of concern. This study aimed to investigate the levels of the herbicide glyphosate and disinfection byproducts in Irish drinking water.
Sewon Lee, Marie A. Coggins, Jim Garvey, Alison Connolly   +3 more
wiley   +1 more source