Results 101 to 110 of about 70,772 (270)

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain.

, 2002
Ionotropic glutamate receptor (iGluR) subunits contain a ∼400-residue extracellular N-terminal domain (“X domain”), which is sequence-related to bacterial amino acid-binding proteins and to class C G-protein-coupled receptors.
Pasternack, A., Coleman, S.K., Jouppila, A., Mottershead, D.G., Lindfors, M., Pasternack, M., Keinänen, K.   +6 more
core   +1 more source

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser, Robert M. Helling, Arn M. J. M. van den Maagdenberg, Josemir W. Sander, Simona Balestrini, Roland D. Thijs   +7 more
wiley   +1 more source

Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis

, 2013
Qingli Li,1,2 Mark J Lambrechts,1 Qiuyang Zhang,1 Sen Liu,1 Dongxia Ge,1 Rutie Yin,2 Mingrong Xi,2 Zongbing You1 1Departments of Structural and Cellular Biology and Orthopaedic Surgery, Tulane Cancer Center and Louisiana Cancer Research Consortium ...
Ge D, You Z, Lambrechts MJ, Yin R, Xi M, Li Q, Liu S, Zhang Q   +7 more
core  

Cornichon-2 Modulates AMPA Receptor–Transmembrane AMPA Receptor Regulatory Protein Assembly to Dictate Gating and Pharmacology

, 2011
Neuronal AMPA receptor complexes comprise a tetramer of GluA pore-forming subunits as well as accessory components, including transmembrane AMPA receptor regulatory proteins (TARPs) and cornichon-2/3 (CNIH-2/3).
He Wang, Martin B. Gill, David S. Bredt, Akihiko S. Kato, Hong Yu, Susumu Tomita, Matthew F. Roberts   +6 more
core   +1 more source

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

, 2021
Regulation of synaptic neurotransmitter receptor content is a fundamental mechanism for tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation.
Angela M. Getz, Mónica Fernández-Monreal, Choquet, Daniel, Matthieu Sainlos, Nowacka, Agata, Breillat, Christelle, Aurélie Lampin-Saint-Amaux, Urielle François, Daniel Choquet, Getz, Angela, François, Urielle, Getz, Angela M., Daburon, Sophie, Getz, Angela, M, Humeau, Yann, Lampin-Saint-Amaux, Aurélie, Zieger, Hanna, Agata Nowacka, Eric Hosy, Sainlos, Matthieu, Fernández-Monreal, Mónica, Lanore, Frédéric, Mathieu Ducros, Ducros, Mathieu, Hosy, Eric, Frédéric Lanore, Hanna L. Zieger, Zieger, Hanna L., Sophie Daburon, Yann Humeau, Christelle Breillat   +30 more
core   +1 more source

Perampanel as add‐on in high‐grade glioma–related epilepsy: Seizure control and QoL in a prospective, multicenter, real‐world 6‐month follow‐up study

Epilepsia Open, EarlyView.
Abstract Objective High‐grade astrocytomas, including glioblastomas, are aggressive brain tumors with poor prognosis and a 5‐year survival below 7%. Seizures affect up to 75% of glioma patients, especially in low‐grade tumors but also in high‐grade cases.
Matteo Impellizzeri, Paolo Paone, Giada Pauletto, Annacarmen Nilo, Simone Beretta, Andrea Salmaggi, Stefano Consoli, Stefano Quadri   +7 more
wiley   +1 more source

Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain

, 2013
Brain damage caused by an acute injury depends on the initial severity of the injury and the time elapsed after the injury. To determine whether these two variables activate common mechanisms, we compared the response of the rat medial septum to insult ...
Andrés, N., Prats Galino, Alberto, Pugliese, Marco, Rodríguez Allué, Manuel José, Mahy Gehenne, Josette Nicole, Malpesa, Y., Batlle, Montserrat   +6 more
core  

AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues

, 2006
The learning processes underlying the formation of drug-cue associations involve changes in synaptic transmission mediated by AMPA receptors. Here, we examine the consequences of targeted deletion of the gene encoding GluR1 subunits of AMPA receptors ...
David N Stephens, Daniel Zamanillo, Andy N Mead (16053851), Nadine Becker (16054313), Mead, AN, Daniel Zamanillo (1859689), Zamanillo, D, Andy N Mead, David N Stephens (16053758), Becker, N, Stephens, DN, Nadine Becker   +11 more
core   +1 more source

SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons

Neuroscience Research
Long-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
doaj   +1 more source