Results 211 to 220 of about 53,551 (310)

TARPγ2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina. [PDF]

eNeuro, 2023
Stincic T, Gayet-Primo J, Taylor WR, Puthussery T.   +3 more
europepmc   +1 more source

Behavioral Abnormalities, Cognitive Impairments, Synaptic Deficits, and Gene Replacement Therapy in a CRISPR Engineered Rat Model of 5p15.2 Deletion Associated With Cri du Chat Syndrome

Advanced Science, Volume 12, Issue 14, April 10, 2025.
A new CdCS rat model is developed using CRISPR‐Cas9 technology. It shows impairments in cognitive and social behaviors, neuronal dendrite abnormalities in the hippocampus and mPFC, and inflammatory and immune processes in mPFC brain cells. Early AAV‐Ctnnd2 gene therapy enhances cognitive function in CdCS rats.
Jingjing Shen, Yan Wang, Yang Liu, Junying Lan, Shuang Long, Yingbo Li, Di Chen, Peng Yu, Jing Zhao, Yongjun Wang, Shali Wang, Feng Yang   +11 more
wiley   +1 more source

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds. [PDF]

Front Pharmacol
Zhigulin AS, Dron MY, Barygin OI, Tikhonov DB.   +3 more
europepmc   +1 more source

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. [PDF]

Nat Commun, 2023
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH.   +7 more
europepmc   +1 more source

EFFECTS OF AMPA/KA RECEPTOR BLOCKADE ON D1 AND D2-LIKE DA RECEPTOR MEDIATED EFFECTS IN NAS CORE AND SHELL

, 1998
Kyoung Ho Choi, Glen B. Baker, Andrew J. Greenshaw   +2 more
openalex   +1 more source

Analog Implementation of a Spiking System for Performing Arithmetic Logic Operations on Mixed‐Signal Neuromorphic Processors

Advanced Intelligent Systems, Volume 7, Issue 4, April 2025.
This article describes the spiking implementation of an arithmetic logic unit, the fundamental basis of which lies in the use of spiking logic gates. An extensive series of experiments validates the implemented designs on SpiNNaker and Dynap‐SE. This work takes a first step in the implementation of a spiking central processing unit.
Alvaro Ayuso‐Martinez, Daniel Casanueva‐Morato, Juan P. Dominguez‐Morales, Giacomo Indiveri, Angel Jimenez‐Fernandez, Gabriel Jimenez‐Moreno   +5 more
wiley   +1 more source

Regulation of different phases of AMPA receptor intracellular transport by 4.1N and SAP97. [PDF]

Elife, 2023
Bonnet C, Charpentier J, Retailleau N, Choquet D, Coussen F.   +4 more
europepmc   +1 more source

Delayed treatment with YM872, a novel AMPA receptor antagonist, reduces ischemic damage in rats with transient middle cerebral artery occlusions.

, 1999
Chikako Ichiki, Sachiko Kawasaki‐Yatsugi, Shin‐ichi Yatsugi, Tokio Yamaguchi   +3 more
openalex   +1 more source

The exocyst and AMPA receptor delivery.

, 2004
Peer ...
Gerges, Nashaat Z., Backos, D. S., Esteban, José A.   +2 more
openaire   +1 more source

Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract Individuals with Down syndrome (DS) are highly susceptible to Alzheimer's disease (AD). The integration of genomics, transcriptomics, epigenomics, proteomics, and metabolomics enables unprecedented understanding of DS‐AD, offering a detailed picture of this complex issue. The vast ‐omics data also present challenges that reflect the complexity
Hui‐Qi Qu, Yichuan Liu, John J. Connolly, Frank D. Mentch, Charlly Kao, Hakon Hakonarson   +5 more
wiley   +1 more source