Results 111 to 120 of about 2,293,512 (363)
Molecular constituents of neuronal AMPA receptors [PDF]
The Journal of Cell Biology, 2005 Dynamic regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) underlies aspects of synaptic plasticity. Although numerous AMPAR-interacting proteins have been identified, their quantitative and relative contributions to native AMPAR complexes remain unclear.
Fukata, Yuko +6 more
openaire +3 more sources
Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment
Cell Biology International, EarlyView.ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty +2 more
wiley +1 more source
Downregulation of GluA2 AMPA receptor subunits reduces the dendritic arborization of developing spinal motoneurons. [PDF]
PLoS ONE, 2012 AMPA receptors lacking the GluA2 subunit allow a significant influx of Ca(2+) ions. Although Ca(2+)-permeable AMPA receptors are a familiar feature at early stages of development, the functional significance of these receptors during the maturation of ...
Yone J Yoon +4 more
doaj +1 more source
AMPA receptors as a molecular target in epilepsy therapy
Acta Neurologica Scandinavica, Supplementum, 2013 Epileptic seizures occur as a result of episodic abnormal synchronous discharges in cerebral neuronal networks. Although a variety of non‐conventional mechanisms may play a role in epileptic synchronization, cascading excitation within networks of ...
Michael A. Rogawski
semanticscholar +1 more source
Potential wells for AMPA receptors organized in ring nanodomains [PDF]
arXiv, 2013 By combining high-density super-resolution imaging with a novel stochastic analysis, we report here a peculiar nano-structure organization revealed by the density function of individual AMPA receptors moving on the surface of cultured hippocampal dendrites.
arxiv
A Thermodynamic Model for Receptor Clustering [PDF]
, 1999 Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv +1 more source
Journal of Neuroscience, 2013 More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 haploinsufficiency is thought to cause ADLTE, the underlying molecular mechanism that results in
Toshika Ohkawa +8 more
semanticscholar +1 more source
Journal of Neuroscience, 2013 Depression is a salient emotional feature of chronic pain. Depression alters the pain threshold and impairs functional recovery. To date, however, there has been limited understanding of synaptic or circuit mechanisms that regulate depression in the pain
Yossef Goffer +8 more
semanticscholar +1 more source
Epilepsia Open, EarlyView.Abstract The Ankyrin 2 (ANK2) gene encodes the ankyrin‐B protein (ANKB), which is involved in the organization and stability of membrane ion channels, transporters, and receptors in cardiomyocytes and neurons. Variants in ANK2 genes are initially reported in long QT syndrome and autism.
Po‐Hsi Lin +5 more
wiley +1 more source
Kidney Research and Clinical Practice, 2014 Background: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and α isoform of calcium/calmodulin-dependent protein kinase II (αCaMKII) is fundamentally ...
Jong Wan Kim +2 more
doaj +1 more source