Results 111 to 120 of about 86,925 (261)

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser, Robert M. Helling, Arn M. J. M. van den Maagdenberg, Josemir W. Sander, Simona Balestrini, Roland D. Thijs   +7 more
wiley   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, EarlyView.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of αCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades

Kidney Research and Clinical Practice, 2014
Background: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and α isoform of calcium/calmodulin-dependent protein kinase II (αCaMKII) is fundamentally ...
Jong Wan Kim, Gyoung Yim Ha, Yong Wook Jung   +2 more
doaj   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source

Metabolism peritumorous zone and alteration AMPAand NMDA-glutamate receptors in the pathogenesis of gliomas of the cerebral hemispheres

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2014
Examined 12 patients with gliomas of the big hemispheres of a brain. Used immunoenzyme method for semiquantitative determination of the level of autoantibodies to NR2A-subunit of NMDA- and GluR1-subunit of AMPA-receptors of glutamate.
V. N. Ochkolyas, G. V. Kataeva
doaj   +1 more source

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses

, 2012
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP ...
A Araque, A Destexhe, AG Nikonenko, AL Hodgkin, AM Weber, AM Zhabotinsky, B Katz, B Mouillac, B Sahin, BL Bloodgood, BL Sabatini, BL Sabatini, C Agulhon, C Agulhon, C Fall, C Henneberger, C Koch, CLM Bon, D Dumitriu, D Sochivko, DJ Hagler Jr, DX Keller, E Neher, EB Malarkey, ER Higgins, F Erler, F Helmchen, F Taqatqeh, G Perea, GA Rameau, GL Collingridge, GW Young De, H-K Lee, HJ Koester, HV McCue, I Nikonenko, I Wenker, J Bai, J Boehm, J Garthwaite, J Kang, J Keener, J Lisman, J Marchaland, J Sneyd, J-W Shuai, JA Bibb, JE Lisman, JH Bollmann, JH Bollmann, JT Porter, Kaushik Majumdar, KD Micheva, KG Phillips, KM Franks, KT Blackwell, L-C Ching, L-Y Wang, LC Griffith, M Mazzanti, M Pittà De, M Tsodyks, MS Jafri, N Aslam, NC Danbolt, NJ Emptage, P Bezzi, P Miller, PP Atluri, R Anwyl, R Bertram, R Llinas, R Schneggenburger, R Schneggenburger, R Vargas, RA Hopper, RC Malenka, RF Fox, RP Munton, S Ben Achour, S Nadkarni, S Nadkarni, Shivendra Tewari, SJ Taylor, T Ishikawa, TA Fiacco, TP Jensen, TVP Bliss, TVP Bliss, V Calabrese, V Montana, V Parpura, V Parpura, V Volman, WT Coffey, Y Watanabe, Y-X Li, Z Nusser   +97 more
core   +1 more source

Neurolathyrism in Sub‐Saharan Africa—Assessing the Neurotoxic Risks of Lathyrus sativus Amid Drought and Food Security Challenges

Food Safety and Health, EarlyView.
Representation of grass pea consumption in drought‐stricken sub‐Saharan Africa sustains nutrition, but excess β‐ODAP exposure due to multiple reasons triggers neurolathyrism, a progressive neurotoxic disorder. ABSTRACT Neurolathyrism is a progressive motor neuron disease due to the consumption of Lathyrus sativus (grass pea) over long periods.
Biruk Demisse Ayalew, Muhammad Umar, Pakeezah Tabasum, Maria Qadri, Talha Farooq, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Eden Haile Hagos, Hailemariam Shimelis Gebeyehu, Hanna Tsehay Abebe, Nuradin Abdi Ali, David Chinaecherem Innocent, Temesgen Mamo Sharew   +12 more
wiley   +1 more source

Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function

Journal of Xenobiotics
Background: Fast excitatory transmission in the central nervous system is carried out by AMPA-type glutamate receptors. Neuronal hyperexcitability and epilepsy have been associated with the dysregulation of AMPA receptor function.
Sosana Bdir, İrfan Çapan, Mohammed Hawash, Süleyman Servi, Mohammad Qneibi   +4 more
doaj   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source