Results 221 to 230 of about 86,925 (261)

Competitive AMPA Receptor Antagonists

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA, COLOTTA, VITTORIA, VARANO, FLAVIA   +2 more
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RNA aptamers for AMPA receptors

Neuropharmacology, 2021
RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors ...
Zhen Huang, Li Niu
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Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins

Neuroscience, 2009
The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
C, Sager, D, Tapken, S, Kott, M, Hollmann   +3 more
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AMPA receptors

Neurology, 2016
In this and forthcoming reviews, a representative clinical case will serve as an introduction to the topic to be discussed. This will provide the basis to address some recent insights from basic neuroscience research on the normal function of the primary target of the disease process involved in the case presented, as well as putative pathophysiologic ...
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Inhibitors of AMPA and Kainate Receptors

Current Medicinal Chemistry, 2001
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen, T B, Stensbøl, P, Krogsgaard-Larsen   +2 more
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AMPA Receptor Cycling in the Synapse

Science's STKE, 2004
Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and,
Anis, Contractor, Stephen F, Heinemann
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AMPA Receptor Trafficking and GluR1

Science, 2005
In their Research Article “Postsynaptic receptor trafficking underlying a form of associative learning” (1 Apr., p. 83), S. Rumpel et al. draw the important conclusions that “encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking” and that “synaptic incorporation of AMPARs is necessary for learning.” The key experiment ...
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Sensitivity of AMPA receptors to pentobarbital

European Journal of Pharmacology: Molecular Pharmacology, 1994
The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
F A, Taverna, B R, Cameron, D L, Hampson, L Y, Wang, J F, MacDonald   +4 more
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The AMPA receptors of auditory neurons

Hearing Research, 2000
The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
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AMPA Receptor Modulator

Science, 2009
A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered.
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