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Amyloid-β-induced dendritic spine elimination requires Ca<sup>2+</sup>-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling, and the NFAT target gene Mdm2. [PDF]
eNeuroMartinez TP +4 more
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Current Medicinal Chemistry, 2001
AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury.
Sham Shridhar Nikam +1 more
openaire +2 more sources
AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury.
Sham Shridhar Nikam +1 more
openaire +2 more sources
Expert Opinion on Therapeutic Patents, 1999
It is now generally recognised that glutamate is the major excitatory neurotransmitter in vertebrate central nervous system (CNS). It acts at ionotropic and metabotropic receptors which appear to play important roles in all aspects of CNS functions. The ionotropic receptors, which are involved in fast synaptic transmission, belong to three subtypes ...
CHIMIRRI, Alba +2 more
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It is now generally recognised that glutamate is the major excitatory neurotransmitter in vertebrate central nervous system (CNS). It acts at ionotropic and metabotropic receptors which appear to play important roles in all aspects of CNS functions. The ionotropic receptors, which are involved in fast synaptic transmission, belong to three subtypes ...
CHIMIRRI, Alba +2 more
openaire +3 more sources
Competitive AMPA Receptor Antagonists
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA +2 more
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Neurology, 2016
In this and forthcoming reviews, a representative clinical case will serve as an introduction to the topic to be discussed. This will provide the basis to address some recent insights from basic neuroscience research on the normal function of the primary target of the disease process involved in the case presented, as well as putative pathophysiologic ...
E. Benarroch
semanticscholar +4 more sources
In this and forthcoming reviews, a representative clinical case will serve as an introduction to the topic to be discussed. This will provide the basis to address some recent insights from basic neuroscience research on the normal function of the primary target of the disease process involved in the case presented, as well as putative pathophysiologic ...
E. Benarroch
semanticscholar +4 more sources
Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins
Neuroscience, 2009The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
Michael Hollmann +3 more
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European Lisp Symposium, 2020
Neuronal communication relies on rapid signalling through chemical synapses. The majority of excitatory neurotransmission in the central nervous system is mediated by binding of glutamate to a family of postsynaptic glutamate receptors.
Alexandra Pinggera, J. Watson, I. Greger
semanticscholar +1 more source
Neuronal communication relies on rapid signalling through chemical synapses. The majority of excitatory neurotransmission in the central nervous system is mediated by binding of glutamate to a family of postsynaptic glutamate receptors.
Alexandra Pinggera, J. Watson, I. Greger
semanticscholar +1 more source
AMPA Receptor Cycling in the Synapse
Science's STKE, 2004Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and,
Anis Contractor, Stephen F. Heinemann
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