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Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins

Neuroscience, 2009
The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
Michael Hollmann   +3 more
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AMPA Receptors

European Lisp Symposium, 2020
Neuronal communication relies on rapid signalling through chemical synapses. The majority of excitatory neurotransmission in the central nervous system is mediated by binding of glutamate to a family of postsynaptic glutamate receptors.
Alexandra Pinggera, J. Watson, I. Greger
semanticscholar   +1 more source

AMPA Receptor Cycling in the Synapse

Science's STKE, 2004
Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and,
Anis Contractor, Stephen F. Heinemann
openaire   +3 more sources

Inhibitors of AMPA and Kainate Receptors

Current Medicinal Chemistry, 2001
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
P. Krogsgaard-Larsen   +2 more
openaire   +3 more sources

AMPA Receptor Modulator

Science Signaling, 2009
A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered.
openaire   +2 more sources

Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.

Science, 1999
Gene-targeted mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure of neuronal dendrites and synapses.
D. Zamanillo   +16 more
semanticscholar   +1 more source

Sensitivity of AMPA receptors to pentobarbital

European Journal of Pharmacology: Molecular Pharmacology, 1994
The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
Lu-Yang Wang   +4 more
openaire   +3 more sources

Stargazin and the AMPA receptor

Science, 2016
Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
openaire   +2 more sources

The AMPA receptors of auditory neurons

Hearing Research, 2000
The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
openaire   +3 more sources

AMPA Receptor Trafficking and GluR1

Science, 2005
In their Research Article “Postsynaptic receptor trafficking underlying a form of associative learning” (1 Apr., p. 83), S. Rumpel et al. draw the important conclusions that “encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking” and that “synaptic incorporation of AMPARs is necessary for learning.” The key experiment ...
openaire   +3 more sources

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