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Recycling Endosomes Supply AMPA Receptors for LTP
Science, 2004Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors.
Mikyoung Park +4 more
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Stargazin and the AMPA receptor
Science, 2016Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
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The AMPA receptors of auditory neurons
Hearing Research, 2000The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
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AMPA Receptor Trafficking and GluR1
Science, 2005In their Research Article “Postsynaptic receptor trafficking underlying a form of associative learning” (1 Apr., p. 83), S. Rumpel et al. draw the important conclusions that “encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking” and that “synaptic incorporation of AMPARs is necessary for learning.” The key experiment ...
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AMPA receptors as drug targets in neurological disease – advantages, caveats, and future outlook
European Journal of Neuroscience, 2012Most excitatory transmission in the brain is mediated by the AMPA receptor subtype of the ionotropic glutamate receptors. In many neurological diseases, synapse structure and AMPA receptor function are altered, thus making AMPA receptors potential ...
P. K. Chang, David Verbich, R. McKinney
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European Journal of Pharmacology, 1996
A series of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) analogues were evaluated for activity at homo-oligomeric glutamate1-flop (Glu1-flop) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique.
Wahl, P +4 more
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A series of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) analogues were evaluated for activity at homo-oligomeric glutamate1-flop (Glu1-flop) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique.
Wahl, P +4 more
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Visualization of AMPA receptors in living human brain with positron emission tomography
Nature Network Boston, 2020Tomoyuki Miyazaki +36 more
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Photocontrol of AMPA Receptors with a Photochromic Ligand
2014Photochromic ligands (PCLs), recently introduced by our group as a tool for researchers in neuroscience, offer the ability to control native receptors with light in a reversible fashion without the need for any genetic manipulation. Here we describe the application of the PCL Azo-Tetrazole-AMPA-3 (ATA-3) to reversibly gate native AMPA-receptors with ...
Martin Sumser, Philipp Stawski
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A Photochromic Agonist of AMPA Receptors
Angewandte Chemie International Edition, 2012Stawski, P.; Sumser, M.; Trauner, D.
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Optical inactivation of synaptic AMPA receptors erases fear memory
Nature Biotechnology, 2016K. Takemoto +7 more
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