Results 81 to 90 of about 593,248 (240)
Exploring the efficacy and safety of perampanel in epilepsia partialis continua: A case series
Epileptic Disorders, EarlyView.Abstract Background Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus (SE), which is commonly drug‐resistant requiring treatment with multiple antiseizure medications (ASM). There are no established guidelines for pharmacological management.
Setareh Lahsaee +3 more
wiley +1 more source
Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses. [PDF]
PLoS ONE, 2013 Postsynatptic density protein (PSD-95) is a 95 kDa scaffolding protein that assembles signaling complexes at synapses. Over-expression of PSD-95 in primary hippocampal neurons selectively increases synaptic localization of AMPA receptors; however, mice ...
Guillermo A Yudowski +4 more
doaj +1 more source
Current Issues in Pharmacy and Medical Sciences, 2009 In acute experiments on 71 white rats by the method of isolated stomach perfusion by Ghosh and Schild it was established that in rats with an intact nervous system antagonist of central and peripheral AMPA/KA glutamate receptors IEM 1751 did not ...
Tetyana Falalyeyeva +2 more
doaj
AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures
Neurobiology of Disease, 1999 Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez +1 more
doaj +1 more source
Homeostatic Scaling of AMPA Receptors by Semaphorin
, 2017 Regulation of AMPA receptors mediates homeostatic scaling. In this issue of Neuron, Wang et al. (2017) identify a new role of secreted semaphorin 3F and elucidate how it triggers synaptic downscaling of AMPA receptors through regulation of the binding of
Nancy Y. Ip +3 more
core +1 more source
Epileptic Disorders, EarlyView.Abstract Objective To compare the incidence of hostility‐ and aggression‐related adverse events in children with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS), receiving perampanel as monotherapy or in combination with other antiseizure medications (ASMs).
Yukitoshi Takahashi +5 more
wiley +1 more source
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
doaj +1 more source
Regulation of AMPA Receptors by Phosphorylation [PDF]
, 2000 The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to ...
Carvalho, Arsélio P. +2 more
core +1 more source
Epilepsia, EarlyView.Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer +7 more
wiley +1 more source
Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
Molecular Brain, 2018 N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission.
Sun Huang +4 more
doaj +1 more source