First Identification of Amphidinols from Mexican Strains and New Analogs [PDF]
Toxins, 2023 The genus Amphidinium has been the subject of recent attention due to the production of polyketide metabolites. Some of these compounds have shown significant bioactivities and could be related to species interactions in the natural benthic ...
Lorena M Durán-Riveroll +2 more
exaly +8 more sources
Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae [PDF]
Marine Drugs, 2019 Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats.
Kevin A. Martínez +11 more
doaj +7 more sources
LC-MS/MS Method Development for the Discovery and Identification of Amphidinols Produced by Amphidinium [PDF]
Marine Drugs, 2020 Amphidinols are polyketides produced by dinoflagellates suspected of causing fish kills. Here, we demonstrate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the identification and quantification of amphidinols (AM).
Marvin Wellkamp +5 more
doaj +7 more sources
High Inter- and Intraspecific Variability in Amphidinol Content and Toxicity of Amphidinium Strains [PDF]
Marine DrugsAmphidinols (AM) are a diverse group of bioactive polyketides produced by dinoflagellates of the genus Amphidinium, known for their hemolytic, antifungal, and cytotoxic activities.
Catharina Alves-de-Souza +6 more
doaj +4 more sources
The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae [PDF]
Marine Drugs, 2017 Two new members of the amphidinol family, amphidinol A (1) and its 7-sulfate derivative amphidinol B (2), were isolated from a strain of Amphidinium carterae of Lake Fusaro, near Naples (Italy), and chemically identified by spectroscopic and ...
Adele Cutignano +2 more
exaly +4 more sources
Effect of Nitrogen, Phosphorous, and Light Colimitation on Amphidinol Production and Growth in the Marine Dinoflagellate Microalga Amphidinium carterae [PDF]
Toxins, 2022 The marine dinoflagellate microalga Amphidinium carterae is a source of amphidinols, a fascinating group of polyketide metabolites potentially useful in drug design.
Alejandro Molina-Miras +5 more
doaj +2 more sources
The Isolation of Specialty Compounds from Amphidinium carterae Biomass by Two-Step Solid-Phase and Liquid-Liquid Extraction [PDF]
Toxins, 2022 The two main methods for partitioning crude methanolic extract from Amphidinium carterae biomass were compared. The objective was to obtain three enriched fractions containing amphidinols (APDs), carotenoids, and fatty acids.
Mercedes López-Rodríguez +8 more
doaj +2 more sources
Acute Toxicity of the Dinoflagellate Amphidinium carterae on Early Life Stages of Zebrafish (Danio rerio) [PDF]
Toxics, 2023 Dinoflagellates of the genus Amphidinium can produce a variety of polyketides, such as amphidinols (AMs), amphidinoketides, and amphidinin, that have hemolytic, cytotoxic, and fish mortality properties.
Xiao Yang +4 more
doaj +2 more sources
Content, Ratio and Productivity of Amphidinols in Wild-Type and Mutagenized Strains of Amphidinium carterae at Different Growth Stages [PDF]
Marine DrugsAs agriculture faces increasing pressure to reduce pesticide residues and heavy metal accumulation in soils, marine microalgae are emerging as sustainable sources of biopesticides.
Ivan Citakovic +6 more
doaj +2 more sources
Antibacterial Activity and Amphidinol Profiling of the Marine Dinoflagellate Amphidinium carterae (Subclade III). [PDF]
Int J Mol Sci, 2021 Microalgae have received growing interest for their capacity to produce bioactive metabolites. This study aimed at characterising the antimicrobial potential of the marine dinoflagellate Amphidinium carterae strain LACW11, isolated from the west of Ireland.
Barone ME +6 more
europepmc +4 more sources