Bioactive Polyketides from Amphidinium spp.: An In-Depth Review of Biosynthesis, Applications, and Current Research Trends [PDF]
Marine DrugsPolyketides (PKs) are a widespread class of secondary metabolites with recognised pharmacological properties. These molecules are abundantly produced in the marine environment, especially by dinoflagellate-photosynthetic organisms able to produce several
Noemi Russo +10 more
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Roles of integral protein in membrane permeabilization by amphidinols
Biochimica Et Biophysica Acta - Biomembranes, 2008 Amphidinols (AMs) are a group of dinoflagellate metabolites with potent antifungal activity. As is the case with polyene macrolide antibiotics, the mode of action of AMs is accounted for by direct interaction with lipid bilayers, which leads to formation of pores or lesions in biomembranes.
Nagy Morsy +2 more
exaly +4 more sources
Amphidinium spp. as a Source of Antimicrobial, Antifungal, and Anticancer Compounds
Life, 2023 Dinoflagellates make up the second largest marine group of marine unicellular eukaryotes in the world ocean and comprise both heterotrophic and autotrophic species, encompassing a wide genetic and chemical diversity.
Ida Orefice +3 more
doaj +2 more sources
Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes [PDF]
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesStructural studies of natural products have been a driving force in the development of organic chemistry throughout its long history, especially in the early years. Recently, structure determination based on new concepts has also gained momentum. In this
Michio MURATA +2 more
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Synthesis of the bis-tetrahydropyran core of amphidinol 3. [PDF]
Org Lett, 2010 A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 is reported. A common intermediate was synthesized from D-tartaric acid utilizing an asymmetric glycolate alkylation/ring-closing metathesis sequence to construct the THP rings.
Crimmins MT, Martin TJ, Martinot TA.
europepmc +5 more sources
Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3. [PDF]
Sci Rep, 2017 AbstractAmphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-channel activity only when sterols were present in
Iwamoto M +5 more
europepmc +4 more sources
Algal amphidinols, an alternative to sulfites in the fight against Brettanomyces bruxellensis
LWT - Food Science and TechnologyThis study evaluated the biocidal activity of a microalgal extract from Amphidinium carterae under oenological conditions to limit Brettanomyces bruxellensis development in red wines over 150 days. Viable and culturable cell concentrations were analyzed during this period.
Hervé Alexandre
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Towards the total synthesis of amphidinol 3
, 2016 Amphidinols are intriguing amphiphilic architectures exhibiting a variety of biological actions, including antifungal, hemolytic, cytotoxic and ichthyotoxic activities. These properties derive from the disturbance of the arrangement of the lipid bilayer of the targeted cells.
Karier, Pol
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Brown Allylation: Application to the Synthesis of Natural Products
European Journal of Organic Chemistry, Volume 2021, Issue 22, Page 3214-3222, June 14, 2021., 2021 The Brown allylation is a well‐known efficient tool for the synthesis of chiral homoallylic alcohols. Here we address the way in which it can be applied to furnish valuable intermediates and versatile building blocks in the synthesis of complex natural products.
Zlata Boiarska +3 more
wiley +1 more source
Karmitoxin: An Amine-Containing Polyhydroxy-Polyene Toxin from the Marine Dinoflagellate Karlodinium armiger. [PDF]
J Nat Prod, 2017 Marine algae from the genus Karlodinium are known to be involved in fish-killing events worldwide. Here we report for the first time the chemistry and bioactivity of a natural product from the newly described mixotrophic dinoflagellate Karlodinium ...
Rasmussen SA +9 more
europepmc +2 more sources