Results 11 to 20 of about 155 (104)

Bioactive Polyketides from Amphidinium spp.: An In-Depth Review of Biosynthesis, Applications, and Current Research Trends [PDF]

Marine Drugs
Polyketides (PKs) are a widespread class of secondary metabolites with recognised pharmacological properties. These molecules are abundantly produced in the marine environment, especially by dinoflagellate-photosynthetic organisms able to produce several
Noemi Russo, Giulia Quaini, Marcello Ziaco, Daniela Castiglia, Alessandra Ruggiero, Vincenzo D’Amelia, Concetta Di Napoli, Sergio Esposito, Angelo Fontana, Genoveffa Nuzzo, Simone Landi   +10 more
doaj   +2 more sources

Antibacterial Activity and Amphidinol Profiling of the Marine Dinoflagellate Amphidinium carterae (Subclade III). [PDF]

Int J Mol Sci, 2021
Microalgae have received growing interest for their capacity to produce bioactive metabolites. This study aimed at characterising the antimicrobial potential of the marine dinoflagellate Amphidinium carterae strain LACW11, isolated from the west of Ireland.
Barone ME, Murphy E, Parkes R, Fleming GTA, Campanile F, Thomas OP, Touzet N.   +6 more
europepmc   +4 more sources

Synthesis of the bis-tetrahydropyran core of amphidinol 3. [PDF]

Org Lett, 2010
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 is reported. A common intermediate was synthesized from D-tartaric acid utilizing an asymmetric glycolate alkylation/ring-closing metathesis sequence to construct the THP rings.
Crimmins MT, Martin TJ, Martinot TA.
europepmc   +5 more sources

Amphidinium spp. as a Source of Antimicrobial, Antifungal, and Anticancer Compounds

Life, 2023
Dinoflagellates make up the second largest marine group of marine unicellular eukaryotes in the world ocean and comprise both heterotrophic and autotrophic species, encompassing a wide genetic and chemical diversity.
Ida Orefice, Sergio Balzano, Giovanna Romano, Angela Sardo   +3 more
doaj   +1 more source

Brown Allylation: Application to the Synthesis of Natural Products

European Journal of Organic Chemistry, Volume 2021, Issue 22, Page 3214-3222, June 14, 2021., 2021
The Brown allylation is a well‐known efficient tool for the synthesis of chiral homoallylic alcohols. Here we address the way in which it can be applied to furnish valuable intermediates and versatile building blocks in the synthesis of complex natural products.
Zlata Boiarska, Tommaso Braga, Alessandra Silvani, Daniele Passarella   +3 more
wiley   +1 more source

Two New Cytotoxic Candidaspongiolides from an Indonesian Sponge

International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011
Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL.
Agus Trianto, Idam Hermawan, Toshimasa Suzuka, Junichi Tanaka, T. Schotten, X.-W. Yang   +5 more
wiley   +1 more source

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Angewandte Chemie, 2018
AbstractAmphidinol 3 (AM3) is a marine natural product produced by the dinoflagellate Amphidinium klebsii. Although the absolute configuration of AM3 was determined in 1999 by extensive NMR analysis and degradation of the natural product, it was a daunting task because of the presence of numerous stereogenic centers on the acyclic carbon chain and the ...
Yuma Wakamiya, Makoto Ebine, Mariko Murayama, Hiroyuki Omizu, Nobuaki Matsumori, Michio Murata, Tohru Oishi   +6 more
openaire   +3 more sources

Amphidinol C, a Major Polyketide from an Irish Strain of the Dinoflagellate Amphidinium Carterae

SSRN Electronic Journal, 2022
An Irish strain of the dinoflagellate Amphidinium carterae was previously shown to produce antibacterial amphidinol derivatives of unknown masses. Inspection of the major metabolites present in a bulk culture of this strain led to the isolation and structure elucidation of a new amphidinol derivative named amphidinol C featuring an unprecedented ...
Murphy E., Barone M. E., Campanile F., Touzet N., Thomas O. P.   +4 more
openaire   +1 more source

Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3. [PDF]

Sci Rep, 2017
AbstractAmphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-channel activity only when sterols were present in
Iwamoto M, Sumino A, Shimada E, Kinoshita M, Matsumori N, Oiki S.   +5 more
europepmc   +4 more sources

Rapid Screening of Polyol Polyketides from Marine Dinoflagellates. [PDF]

Anal Chem, 2022
Morales-Amador A, Souto ML, Hertweck C, Fernández JJ, García-Altares M.   +4 more
europepmc   +1 more source