Results 111 to 120 of about 381,413 (281)

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. [PDF]

J Med Chem, 2022
Mohammed EHM, Lohan S, Ghaffari T, Gupta S, Tiwari RK, Parang K.   +5 more
europepmc   +1 more source

Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides [PDF]

, 2011
Bacterial endotoxins (lipopolysaccharides (LPS)) are strong elicitors of the human immune system by interacting with serum and membrane proteins such as lipopolysaccharide-binding protein (LBP) and CD14 with high specificity. At LPS concentrations as low
Brauser, A. (Annemarie), Razquin-Olazaran, I. (Iosu), Kaconis, Y. (Yani), Jörg Howe, Brandenburg, K. (Klaus), Howe, J. (Jörg), Iosu Razquin-Olazarán, Rossle, M. (Manfred), Patrick Garidel, Iñigo, M. (Melania), Kowalski, I. (Ina), Ina Kowalski, Walter Richter, Martinez-de-Tejada, G. (Guillermo), Yani Kaconis, Klaus Brandenburg, Annemarie Brauser, Melania Iñigo-Pestaña, Garidel, P. (Patrick), Richter, W. (Walter), Manfred Rössle, Thomas Gutsmann, Gutsmann, T. (Thomas), Guillermo Martinez de Tejada   +23 more
core   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Cross‐linked Triblock Peptide Capsules as Potential Oxygen Carriers

ChemistryOpen
Perfluorodecalin (PFD)‐filled capsules have been studied for over 15 years as artificial oxygen carriers. However, none of these capsules combines good biocompatibility, good mechanical stability and dispersion stability. Here we propose to use synthetic
Huayang Feng, Jürgen Linders, Miriam Cantore, Jonas Fabrizi, Annika Kirsten, Sascha Myszkowska, Eva Hillen, Florian Uteschil, Sebastian Buchholz, Andrea Hermsen, Maria Davila Garvin, Katja Bettina Ferenz, Christian Mayer   +12 more
doaj   +1 more source

Interaction between glyphosate pesticide and amphiphilic peptides for colorimetric analysis. [PDF]

Nanoscale Adv, 2022
Gerbelli BB, Filho PLO, Cortez B, Sodré PT, Coutinho-Neto MD, Hamley IW, Seitsonen J, Alves WA.   +7 more
europepmc   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Enhanced translocation of amphiphilic peptides across membranes by transmembrane proteins. [PDF]

Biophys J, 2021
Bartoš L, Kabelka I, Vácha R.
europepmc   +1 more source