Results 131 to 140 of about 381,413 (281)

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

Angewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source

Impact of stereochemical replacement on activity and selectivity of membrane-active antibacterial and antifungal cyclic peptides

npj Antimicrobials and Resistance
Herein, we report a library of 7-mer macrocyclic peptides designed by systematically replacing one, multiple, or all L-amino acids with their D-isomers in our previously identified hit compounds. Lead peptides, 15c and 16c, showed broad-spectrum activity
Sandeep Lohan, Anastasia G. Konshina, Eman H. M. Mohammed, Naiera M. Helmy, Srishhti K. Jha, Rakesh Kumar Tiwari, Innokentiy Maslennikov, Roman G. Efremov, Keykavous Parang   +8 more
doaj   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Amphiphilic Four-Helix Bundle Peptides Designed for Light-Induced Electron Transfer Across a Soft Interface

, 2016
A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior.
Sophia P. Wu (2520853), Thomas Gog (2520856), Dror Noy (1913644), Michael J. Therien (1371579), J. Kent Blasie (1317141), Bohdana M. Discher (2180954), P. Leslie Dutton (1309374), Joseph Strzalka (1477027), Shixin Ye (1994149), Ivan Kuzmenko (1268562), Ting Xu (215531)   +10 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The study of cationic amphiphilic peptides with anti-cancer selective toxicity [PDF]

, 2014
A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. Johannesburg, 2014.The exposure of organisms to environmental stresses and pathogens
Maumela, Pfariso
core  

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Impact of Amphiphilic Balance on Nano–Bio Interactions of Peptide Amphiphile Nanostructures

ACS Applied Materials & Interfaces
Abstract Self-assembled peptide amphiphile (PA)-based nanostructures are promising biomaterials with their biocompatibility and highly tunable physical and chemical properties. Despite this promise, the interactions of PA nanostructures with biological systems have remained largely unexplored.
Karla Bonic, Kailin Mooney, Li Xiang, Sadik Esener, Adem Yildirim   +4 more
openaire   +2 more sources

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

The First Example of a Model Amphiphilic Polymer Conetwork Containing a Hydrophobic Oligopeptide: The Case of End-Linked Tetra[Poly(ethylene glycol)-b-oligo(L-alanine)]

Gels
Herein we describe the development of the first model amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(L-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol ...
Demetris E. Apostolides, George Michael, Costas S. Patrickios, Takamasa Sakai, Iro Kyroglou, Maria Kasimatis, Hermis Iatrou, Sylvain Prévost, Michael Gradzielski   +8 more
doaj   +1 more source