Results 91 to 100 of about 374,595 (258)

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

open access: yesDrug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler   +4 more
wiley   +1 more source

Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B

open access: yesWorld Journal of Otorhinolaryngology-Head and Neck Surgery, 2017
Objective: Amphotericin B (AMB), a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) for the treatment of fungal ...
Do-Yeon Cho   +7 more
doaj  

Sharp power means bounds for Neuman-Sándor mean [PDF]

open access: yesarXiv, 2012
For a,b>0 with a\not=b, let N(a,b) denote the Neuman-S\'andor mean defined by N(a,b)=((a-b)/(2arcsinh((a-b)/(a+b)))) and A_{r}(a,b) denote the r-order power mean. We present the sharp power means bounds for the Neuman-S\'andor mean: A_{p_1}(a,b)
arxiv  

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

open access: yesDrug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman   +9 more
wiley   +1 more source

Cliques in the union of $C_4$-free graphs [PDF]

open access: yesarXiv, 2015
Let $B$ and $R$ be two simple graphs with vertex set $V$, and let $G(B,R)$ be the simple graph with vertex set $V$, in which two vertices are adjacent if they are adjacent in at least one of $B$ and $R$. We prove that if $B$ and $R$ are two $C_4$-free graphs on the same vertex set $V$ and $G(B,R)$ is the complete graph, then there exists an $B$-clique $
arxiv  

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

open access: yesDrug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer   +13 more
wiley   +1 more source

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor   +3 more
wiley   +1 more source

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