Results 161 to 170 of about 91,427 (251)

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Local amphotericin B for a neglected <i>Rhizopus microsporus</i> necrotizing soft tissue infection following crush syndrome: a case report. [PDF]

Front Med (Lausanne)
Yan W, Li Z, Wang L, Zhang J, Chen P.
europepmc   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Candidozyma auris-infected Galleria mellonella larvae: the effect of the humanized monoclonal antibody Dia-T51 and its synergy with amphotericin B. [PDF]

NPJ Antimicrob Resist
Vanzolini T, Fiori V, Magnani M.
europepmc   +1 more source

Development and Validation of a Viability RT‐qPCR Assay for Detecting Infectious Spring Viraemia of Carp Virus (SVCV)

Journal of Fish Diseases, Volume 49, Issue 8, August 2026.
ABSTRACT Spring viremia of carp virus (SVCV) is a contagious pathogen associated with significant mortality and economic losses in freshwater aquaculture. Although reverse transcription quantitative PCR (RT‐qPCR) enables rapid detection, it does not distinguish between infectious and non‐infectious viral particles, which may lead to overestimation of ...
Ha‐Jeong Son, Min‐Young Sohn, Jae‐Ok Kim, Hee Jung Choi, Mun‐Gyeong Kwon, Jeong‐Tae Lee, Gyoungsik Kang, HyeongJin Roh, Chan‐Il Park, Kyung‐Ho Kim   +9 more
wiley   +1 more source

Real-World Outcomes of Amphotericin B Colloidal Dispersion as Salvage Therapy for Invasive Fungal Disease. [PDF]

Drug Des Devel Ther
Jiang M, Li W, Tian L, Xu D, Fan Y, Liu D, He Y.   +6 more
europepmc   +1 more source

Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Background Helicobacter spp. are gastric or enterohepatic bacteria that can be commensal, opportunistic, or pathogenic. Few studies have evaluated Helicobacter spp. in baboons. Methods Twenty‐seven captive baboons were surveyed for Helicobacter spp. by fecal PCR, and a subset evaluated by culture.
Isabel A. Jimenez, Courtney Lunger, Marcus J. Crim, Shannon L. Primm, Anthony Mannion, Nathan P. Crilly, Lydia M. Hopper, Lindsey G. Thurman, Linnette L. Vasquez, Cory Brayton, Yan Feng, James G. Fox, Zeli Shen, Jessica M. Izzi   +13 more
wiley   +1 more source

Synergistic Effect of 5-Fluorouracil and Amphotericin B in Murine Paracoccidioidomycosis: Immune Modulation and Enhanced Fungal Clearance. [PDF]

ACS Infect Dis
Franco FN, Dos Santos ACS, Dos Santos BV, Preite NW, Molist-Homs C, de Oliveira LFF, Borges BM, Loures FV.   +7 more
europepmc   +1 more source

Environmental Distribution of Pathogenic Leptospira spp. in Subtropical Rivers of Japan and Implications for Human Infection

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1073-1081, August 2026.
ABSTRACT Objectives Leptospirosis is a zoonotic disease caused by Leptospira spp. often linked to freshwater exposure in subtropical and tropical regions. Okinawa Prefecture reports the highest number of leptospirosis cases in Japan based on national surveillance data.
Atsuhiro Kanayama, Hiroko Ejiri, Yuki Chiko, Ikumi Namihira, Tomoki Yonaha, Kanetaka Kuba, Miyu Yoshimi, Nobuo Koizumi, Shigeto Takeshima, Koki Kaku   +9 more
wiley   +1 more source

Emerging evidence for a multitude of mechanisms and factors that determine amphotericin B resistance in pathogenic fungi. [PDF]

Cell Surf
Chauhan A, Gow NAR, Prasad R.
europepmc   +1 more source