Results 101 to 110 of about 348,393 (352)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Investigation of using Fenton oxidation process for ampicillin and ciprofloxacin removal from hospital wastewater [PDF]

فصلنامه ابن سینا, 2017
Background: Antibiotics are one of the most important pollutants of the aqueous environments. In this study, the efficiency of Fenton advanced oxidation process to remove the antibiotics (ciprofloxacin and ampicillin) was investigated.
F Teymoori, V Pesarakloo, H Ghafourian, M Kashefiol asl   +3 more
doaj  

Production and characterization of a single-chain Fv antibody–alkaline phosphatase fusion protein specific for ampicillin

Food and Agricultural Immunology, 2019
Anti-AMP scFv were prepared by cloning variable region genes (VH and VL) from hybridoma cell line which secretes antibodies against AMP, and phoA gene was cloned from Escherichia coli strain K12 chromosomal DNA.
Kuo He, Fan Wei, Xiuyuan Zhang, Jiayi Li, Donghao Zhang, Dong Wei   +5 more
doaj   +1 more source

Antibiotic sensitivities of urinary tract pathogenes in Maltese patients [PDF]

, 1993
A survey of over 1000 bacterial isolates from Maltese patients with urinary tract infection was performed in order to investigate resistance patterns to commonly used oral antibiotics.
Borg, Michael Angelo
core  

“An antibiotic turned contraceptive”: The tale of ampicillin‐cloxacillin

, 2022
Chinonyerem O. Iheanacho
openalex   +1 more source

Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface‐enhanced Raman Spectroscopy

Advanced Science, EarlyView.
Gold nanostar‐enhanced Raman spectroscopy (SERS) enables real‐time, label‐free tracking of levofloxacin diffusion in intact biofilms. Nanostars embedded 16 µm below the surface detect drug arrival over time, revealing the impact of the biofilm matrix on antibiotic transport. Abstract The increased resistance to antibiotics shown by bacteria in biofilms
Wafaa Aljuhani, Yingrui Zhang, Matthew P. Wylie, Colin P. McCoy, Steven E. J. Bell   +4 more
wiley   +1 more source

Assessment the risk factors of gastroenteritis and the role of antibiotics used Ampicillin and Ampicillin plus Amikacin in the treatment among children aged 3-60 months from 1-7-2013 to 1-10 2013 in Kamal Odwan Hospital, prospective study.

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014
The term gastroenteritis denotes infections of the gastrointestinal (GI) tract caused by bacterial, viral, parasitic pathogens or chemical agents and food intolerance, none of which requires antimicrobial therapy.
Hashem M. Mansour
doaj  

A multicenter comparative study of cefepime versus broad-spectrum antibacterial therapy in moderate and severe bacterial infections

Brazilian Journal of Infectious Diseases
The safety and efficacy of cefepime empiric monotherapy compared with standard broad-spectrum combination therapy for hospitalized adult patients with moderate to severe community-acquired bacterial infections were evaluated.
Roberto Badaró, Fernando Molinar, Carlos Seas, Daniel Stamboulian, João Mendonça, João Massud, Luiz Olympio Nascimento   +6 more
doaj   +1 more source

Stephania suberosa Forman extract synergistically inhibits ampicillin- and vancomycin-resistant Enterococcus faecium

, 2023
Yothin Teethaisong, Piyasiri Chueakwon, Kulwara Poolpol, Intu-orn Ayamuang, Siriporn Suknasang, Chittadech Apinundecha, Griangsak Eumkeb   +6 more
openalex   +1 more source