Results 51 to 60 of about 405,864 (350)

Extracting Conformational Ensembles of Small Molecules from Molecular Dynamics Simulations: Ampicillin as a Test Case

Computation, 2016
The accurate and exhaustive description of the conformational ensemble sampled by small molecules in solution, possibly at different physiological conditions, is of primary interest in many fields of medicinal chemistry and computational biology ...
Giuliano Malloci, Giovanni Serra, Andrea Bosin, Attilio Vittorio Vargiu   +3 more
doaj   +1 more source

Toxin ζ Reversible Induces Dormancy and Reduces the UDP-N-Acetylglucosamine Pool as One of the Protective Responses to Cope with Stress

Toxins, 2014
Toxins of the ζ/PezT family, found in the genome of major human pathogens, phosphorylate the peptidoglycan precursor uridine diphosphate-N-acetylglucosamine (UNAG) leading to unreactive UNAG-3P.
Mariangela Tabone, Silvia Ayora, Juan C. Alonso   +2 more
doaj   +1 more source

Simultaneous Quantification of Ampicillin and Kanamycin in Water Samples Based on Lateral Flow Aptasensor Strip with an Internal Line

Molecules, 2021
In this work, a simple and rapid method based on the lateral flow assay (LFA) has been developed for the detection of dual antibiotics. To achieve the quantitative assay and to reduce the non-specific adsorption, an internal system has been developed.
Jinbiao Lin, Ang Shi, Ziwu Zheng, Long Huang, Yixin Wang, Honggui Lin, Xuexia Lin   +6 more
doaj   +1 more source

Multidrug-resistant Escherichia coli, Klebsiella pneumoniae and Staphylococcus spp. in houseflies and blowflies from farms and their environmental settings [PDF]

, 2019
Background: Antimicrobial resistance is rising globally at an alarming rate. While multiple active surveillance programs have been established to monitor the antimicrobial resistance, studies on the environmental link to antimicrobial spread are lacking.
Adekanmbi, Folesade, Butaye, Patrick, Cattley, Russell, Hathcock, Terri, Kalalah, Anwar, Kang, Yuan, Macklin, Kenneth, Poudel, Anil, Price, Stuart, Walz, Paul, Wang, Chengming   +10 more
core   +1 more source

Mortality rate in patients with nosocomial Acinetobacter meningitis from a Brazilian hospital

Brazilian Journal of Infectious Diseases
BACKGROUND: The mortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high. OBJECTIVE: The aim of this study was to evaluate the factors that have influence over the outcomes in ANM patients. METHODS: A retrospective analysis of 22
Felipe Francisco Tuon, Sergio R Penteado-Filho, Diogo Amarante, Marcio A Andrade, Luis A Borba   +4 more
doaj   +1 more source

Eradication, Strain Preservation, Strain Change — Outcomes of Helicobacter pylori Therapy

Антибиотики и Химиотерапия, 2021
Relevance. If we reduce the treatment exclusively to the eradication of Helicobacter pylori (Hp), the question of monitoring the results of anti-Hp therapy is controversial, given the widely known data on the detection of Hp, including virulent strains ...
E. V. Golubkina, V. M. Sorokin, B. N. Levitan, A. R. Umerova, N. V. Kamneva   +4 more
doaj   +1 more source

Seasonal variations in antibiotic resistance gene transport in the Almendares River, Havana, Cuba [PDF]

, 2012
Numerous studies have quantified antibiotic resistance genes (ARG) in rivers and streams around the world, and significant relationships have been shown that relate different pollutant outputs and increased local ARG levels.
Charles W Knapp, Charles W Knapp, David eWerner, David W eGraham, Emma eBowen, Lazaro eLima, Susana eOlivares-Rieumont   +6 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhanced antibiotic activity of ampicillin conjugated to gold nanoparticles on PEGylated rosette nanotubes

International Journal of Nanomedicine, 2019
Purpose This work presents the preparation of a nanocomposite of ampicillin-conjugated gold nanoparticles (AuNPs) and self-assembled rosette nanotubes (RNTs), and evaluates its antibacterial properties against two strains of drug-resistant bacteria ...
Yiwen Fan, Alexander C Pauer, Arthur A. Gonzales, H. Fenniri   +3 more
semanticscholar   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source