Results 181 to 190 of about 3,637,465 (291)

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant   +9 more
wiley   +1 more source

A Visual Analogue Scale Exercise for Teaching Antimicrobial Selection in Veterinary Pharmacology: Tool Development and Initial Implementation

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Veterinary students often find it difficult to select antimicrobial drugs for patients, likely because it requires them to consider multiple factors and there are frequently several possible options with a lack of a defined “correct or incorrect” choice. Our goal was to develop a teaching tool to engage the students through the decision‐making
Carly A. Patterson   +2 more
wiley   +1 more source

The Absence of E. coli Nucleoid‐Associated Protein FIS at Low Temperature Leads to an Adaptation Response That Causes a Shift Towards Genome Compaction in Small Rods

open access: yesMolecular Microbiology, EarlyView.
Unlike the wild‐type BW25113, the fis null mutant is characterized by biphasic growth at 12°C. During the first phase of growth, the absence of FIS results in the formation of filaments with dispersed nucleoids. During the acclimation phase, the FIS Null Adaptation Response is activated that leads to an increase in cell division and nucleoid ...
Pamela G. Jones
wiley   +1 more source

Protein STM3547 From Salmonella typhimurium Is a Phosphofructose Kinase B‐Type Enzyme With Ribose Kinase Activity

open access: yesMolecular Microbiology, EarlyView.
The metabolism of ribose starts with the phosphorylation of its 5′ hydroxyl group. Salmonella typhimurium has two kinases that perform this function, namely ribose rinase (RbsK) and deoxyribose kinase (DeoK). Here we report a new ribose kinase that we named RikA. The illustration was partially created in BioRender.
Regan D. McCormick   +2 more
wiley   +1 more source

Research Progress on perinatal <i>E. coli</i> infection. [PDF]

open access: yesFront Microbiol
Lin Y   +6 more
europepmc   +1 more source

Elucidating the Staphylococcus aureus TSST‐1 Regulatory Network as a Response to Vaginal pH

open access: yesMolecular Microbiology, EarlyView.
Toxic shock syndrome toxin‐1 (TSST‐1) is a potent Staphylococcus aureus superantigen responsible for menstrual toxic shock syndrome (mTSS). Regulation of TSST‐1 is controlled by multiple systems including the stand‐alone transcriptional regulators CcpA and SarA and two‐component systems including the redox sensor SrrAB, the membrane stress sensor SaeRS,
Carla S. Maduta   +5 more
wiley   +1 more source

A Phosphorylation‐Dependent Partner‐Switching‐Like Module Regulates a Glycosyltransferase Required for Heterocyst Polysaccharide Layer Formation in Anabaena sp. Strain PCC 7120

open access: yesMolecular Microbiology, EarlyView.
The glycosyltransferase All4160 is regulated by the reversible phosphorylation of Ser74. The kinase Alr3423 phosphorylates and inactivates All4160, while the SpoIIE‐like phosphatase HenR restores its activity through dephosphorylation. A nonphosphorylatable variant of All4160 bypasses the need for HenR, which demonstrates that a phosphorylation ...
Mai Harada   +2 more
wiley   +1 more source

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