Results 211 to 220 of about 112,937 (259)

Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition. [PDF]

PLoS Pathog
Xu T, Cao W, Fan S, Liu R, Zhu H, Lu X, Zhang Z, He X, Zhang K, Huang J, Ma N, Chang G, Yang Z.   +12 more
europepmc   +1 more source

AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming. [PDF]

J Mol Cell Biol
Wang H, Wang G, Yin T, Li H, Wang H, Shao Y, Li Y, Hua R, Li J, Zang Y.   +9 more
europepmc   +1 more source

AMPK against NASH [PDF]

Nature Reviews Molecular Cell Biology, 2020
A new study in Science shows that AMPK is an inhibitor of caspase 6-driven hepatic cell death in non-alcoholic steatohepatitis.
exaly   +3 more sources

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AMPK moonlights in mitosis

Nature Reviews Molecular Cell Biology, 2012
Katharine H Wrighton
exaly   +3 more sources

AMPK and vasculoprotection

Pharmacology & Therapeutics, 2011
AMP-activated protein kinase (AMPK) is proposed to be a key regulator of cellular and organismal metabolism and has reported vasculoprotective effects. In addition, many therapeutic agents used in the treatment of diabetes and atherosclerosis such as metformin, thiazolidinediones and statins may exert their vasculoprotective effects through activation ...
Marie-Ann, Ewart, Simon, Kennedy
openaire   +2 more sources

AMPK-sensitive cellular transport

Journal of Biochemistry, 2014
The energy sensing AMP-activated protein kinase (AMPK) regulates cellular and whole-body energy balance through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy depletion. The kinase has previously been reported to be either directly or indirectly involved in the regulation
Dërmaku Sopjani M., Abazi S., FAGGIO, Caterina, Kolgeci J., Sopjani M.   +4 more
openaire   +2 more sources

AMPK and Autophagy

2019
AMPK is an evolutionarily conserved serine/threonine-protein kinase that acts as an energy sensor in cells and plays a key role in the upregulation of catabolism and inactivation of anabolism. Under various physiological and pathological conditions, AMPK can be phosphorylated by an upstream kinase and bind to AMP or ADP rather than ATP, leading to its ...
Yanjun, Li, Yingyu, Chen
openaire   +2 more sources