Results 51 to 60 of about 228,730 (331)
Aging, 2020 Ischemia/reperfusion (I/R) injury is a life-threatening vascular emergency following myocardial infarction. Our previous study showed cardioprotective effects of metformin against myocardial I/R injury.
Jing Zhang +12 more
semanticscholar +1 more source
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations [PDF]
, 2004 CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms of life. Although thought to be regulatory, their exact functions have been unknown.
Anis, Miliea +7 more
core +6 more sources
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
Cells, 2021 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer ...
D. Visnjic +4 more
semanticscholar +1 more source
Bypassing AMPK Phosphorylation
Chemistry & Biology, 2014 AMP-activated protein kinase (AMPK) functions as a signaling hub to balance energy supply with demand. Phosphorylation of activation loop Thr172 has been considered as an essential step in AMPK activation. In this issue of Chemistry & Biology, Scott and colleagues show that the small molecule direct AMPK activator, A-769662, bypasses this ...
Viollet, Benoit +2 more
openaire +3 more sources
, 2016 During host-pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection.
Mesquita, Inês +7 more
openaire +4 more sources
Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. [PDF]
, 2020 Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling.
Cao, Jimin +11 more
core +1 more source
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses
Autophagy, 2020 Energy deprivation activates the cellular energy sensor AMP-activated protein kinase (AMPK), which in turn induces macroautophagy/autophagy. The mitochondrial-associated ER membrane (MAM) plays a key role in mitochondrial division and autophagy, and the ...
Yongquan Hu +15 more
semanticscholar +1 more source
AMPK protects against alcohol-induced liver injury through UQCRC2 to up-regulate mitophagy
Autophagy, 2021 Recent reports indicated that mitophagy protects against alcohol-induced liver injury, which helps remove damaged mitochondria to reduce the accumulation of reactive oxygen species (ROS). AMP-activated protein kinase (AMPK) has been recently used in ALD (
Xinyi Lu +5 more
semanticscholar +1 more source
LKB1-AMPK axis revisited [PDF]
Cell Research, 2012 The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis, AMPK.
Filippos, Kottakis, Nabeel, Bardeesy
openaire +2 more sources
Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b
Clinical and Experimental Hypertension, 2017 Background: Berberine has several preventive effects on cardiovascular diseases. Increased expression of miR-29b has been reported to attenuate cardiac remodeling after myocardial infarction (MI).
Mo-Li Zhu +6 more
doaj +1 more source