Results 51 to 60 of about 117,713 (263)

AMP-activated protein kinase promotes breast cancer stemness and drug resistance

Disease Models & Mechanisms, 2022
Breast cancer stem cells (BCSCs) are a major cause of therapy resistance and tumour progression. Currently, their regulation is not entirely understood.
Sai Balaji Andugulapati, Ananthalakshmy Sundararaman, Mohini Lahiry, Annapoorni Rangarajan   +3 more
doaj   +1 more source

Bypassing AMPK Phosphorylation

Chemistry & Biology, 2014
AMP-activated protein kinase (AMPK) functions as a signaling hub to balance energy supply with demand. Phosphorylation of activation loop Thr172 has been considered as an essential step in AMPK activation. In this issue of Chemistry & Biology, Scott and colleagues show that the small molecule direct AMPK activator, A-769662, bypasses this ...
Viollet, Benoit, Foretz, Marc, Schlattner, Uwe   +2 more
openaire   +3 more sources

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Comparative Effects of Intermittent Fasting and Swimming Exercise on Metabolic Markers and White Adipose Tissue Browning in High-Fat Diet-induced Obese Mice [PDF]

운동과학
PURPOSE This study aimed to compare the effects of intermittent fasting (IF) and swimming exercise (SE) on metabolic markers and white adipose tissue (WAT) browning in high-fat diet (HFD)-induced obese mice.
Eunhee Cho, Subin Park, Chaeeun Cho, Sewon Lee   +3 more
doaj   +1 more source

Ex vivo gut culture for studying differentiation and migration of small intestinal epithelial cells [PDF]

Open Biology, 2018
Epithelial cultures are commonly used for studying gut health. However, due to the absence of mesenchymal cells and gut structure, epithelial culture systems including recently developed three-dimensional organoid culture cannot accurately represent in ...
Xiaofei Sun, Xing Fu, Min Du, Mei-Jun Zhu   +3 more
doaj   +1 more source

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Molecular Metabolism, 2020
Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module (CBM). However, the physiological role of AMPK-glycogen binding in energy homeostasis has not been investigated in vivo. This study aimed to
Nolan J. Hoffman, Jamie Whitfield, Natalie R. Janzen, Mehdi R. Belhaj, Sandra Galic, Lisa Murray-Segal, William J. Smiles, Naomi X.Y. Ling, Toby A. Dite, John W. Scott, Jonathan S. Oakhill, Robert Brink, Bruce E. Kemp, John A. Hawley   +13 more
openaire   +5 more sources

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation

Drug Design, Development and Therapy, 2020
Min Han,1– 3 Ying Cao,2 Hao Xue,1 Xili Chu,2 Tingting Li,2 Danqing Xin,2 Lin Yuan,2 Hongfei Ke,2 Gang Li,1 Zhen Wang2 1Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’
Han M, Cao Y, Xue H, Chu X, Li T, Xin D, Yuan L, Ke H, Li G, Wang Z   +9 more
doaj  

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent [PDF]

Molecular Cancer Therapeutics, 2014
Abstract AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor important for cell growth, proliferation, survival, and metabolic regulation. Active AMPK inhibits biosynthetic enzymes like mTOR and acetyl CoA carboxylase (required for protein and lipid synthesis, respectively) to ensure that cells maintain ...
Xiaona, Liu, Rishi Raj, Chhipa, Ichiro, Nakano, Biplab, Dasgupta   +3 more
openaire   +2 more sources