Results 111 to 120 of about 549,161 (310)

Modelling of two-, threesection TWT of O-type of teraherts band frequencies

open access: yesВесці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2016
A analysis of physical processes in TWT on folded waveguide with a consecutive and parallel arrangement of sections concerning electronic beams is carried out. Features and advantages of different construction of amplifiers are noted.
A. V. Aksenchyk   +2 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Modeling and optimizing of nonlinear electromagnetic processes. Non-synchronous interaction of free electrons with the electromagnetic radiation field

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The main results of the researches in the scientific direction «Modeling and optimizing nonlinear electromagnetic processes» for 2013-2018 years are presented.
A. A. Kurayev, V. V. Matveyenka
doaj  

Design and Realization of Ultra-Wideband Differential Amplifiers for M-Sequence Radar Applications

open access: yesSensors
Amplification of wideband high-frequency and microwave signals is a fundamental element within every high-frequency circuit and device. Ultra-wideband (UWB) sensor applications use circuits designed for their specific application.
Miroslav Sokol   +2 more
doaj   +1 more source

Transient augmentation circuit for pulse amplifiers Patent [PDF]

open access: yes, 1966
Digital data handling circuits for pulse ...
Benedict, R. D.
core   +1 more source

Passive alignment stability and auto-alignment of multipass amplifiers based on Fourier transforms

open access: yes, 2019
The stability properties of Fourier-based multipass amplifier to misalignments (tilts) of its optical components has been investigated. For this purpose, a method to quantify the sensitivity to tilts based on the amplifier small signal gain has been ...
Antognini, Aldo   +10 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Temperature sensitive oscillator [PDF]

open access: yes, 1986
An oscillator circuit for sensing and indicating temperature by changing oscillator frequency with temperature comprises a programmable operational amplifier which is operated on the roll-off portion of its gain versus frequency curve and has its output ...
Kleinberg, L. L.
core   +1 more source

Design and characterization of a lumped element single-ended superconducting microwave parametric amplifier with on-chip flux bias line

open access: yes, 2013
We demonstrate a lumped-element Josephson parametric amplifier, using a single-ended design that includes an on-chip, high-bandwidth flux bias line. The amplifier can be pumped into its region of parametric gain through either the input port or through ...
Barends, Rami   +20 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy