Results 51 to 60 of about 375,907 (328)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Secrecy Performance Analysis of Relay Selection in Cooperative NOMA Systems

IEEE Access, 2019
This paper investigates the security performance of two relay selection schemes for cooperative non-orthogonal multiple access (NOMA) systems, where K randomly distributed relays are employed with either decode-and-forward (DF) or amplify-and-forward (AF)
Zhenling Wang, Zhangyou Peng
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimal relay selection scheme and outage probability analysis in cooperative wireless networks

Dianxin kexue, 2018
Optimal relay selection can effectively improve the system performance in the communication network with cooperative relays from the view of physical layer security.The optimal relay selection schemes for relay transmission system with multiple single ...
Youhong FENG, Zhi YANG, Xuxing DING, Xuefeng YUE, Qiqi LI, Xiaojuan Xie   +5 more
doaj   +2 more sources

Adaptive AF/DF Selection With FD/HD Switching in Two-Way Relay Networks

IEEE Access, 2017
The full-duplex (FD) and two-way relay are promising techniques for their high spectrum efficiency. However, the incompletely self-interference cancellation may reduce the performance gain of two-way relay networks, which operates in FD mode.
Quanqiang Miao, Bo Bai, Wei Chen
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Secure Transmission in Amplify-and-Forward Diamond Networks with a Single Eavesdropper

, 2015
Unicast communication over a network of $M$-parallel relays in the presence of an eavesdropper is considered. The relay nodes, operating under individual power constraints, amplify and forward the signals received at their inputs.
Agnihotri, Samar, Kuri, Joy, Sarma, Siddhartha   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Optimal space-time codes for the MIMO amplify-and-forward cooperative channel

, 2006
In this work, we extend the non-orthogonal amplify-and-forward (NAF) cooperative diversity scheme to the MIMO channel. A family of space-time block codes for a half-duplex MIMO NAF fading cooperative channel with N relays is constructed.
Belfiore, Jean-Claude, Yang, Sheng
core   +7 more sources