Results 61 to 70 of about 148,461 (296)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Exploiting Sparsity in Amplify-and-Forward Broadband Multiple Relay Selection
IEEE Access, 2019 Cooperative communication has attracted significant attention in the last decade due to its ability to increase the spatial diversity order with only single-antenna nodes.
Ala Gouissem +3 more
doaj +1 more source
, 2012 In this paper, we consider a dual-hop multiplerelay network with orthogonal frequency division multiplexing (OFDM) based Amplify-and-Forward (AF) relay protocol over frequency-selective channels. In practice, subcarriers suffered that suffer deep fade in
Xiang, Wei +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Localizing Noncooperative Receiver Through Full-Duplex Amplify-and-Forward Relay
IEEE Access, 2018 Localizing noncooperative transmitter (Tx) and receiver (Rx) that belong to another system is important in many scenarios, e.g., interference management in cognitive radio systems and user behavior learning in ad hoc wireless networks. However, obtaining
Chuanxue Jin +4 more
doaj +1 more source
Signal-to-Noise Ratio Comparison of Amplify-Forward and Direct Link in Wireless Sensor Networks [PDF]
, 2007 We compare the signal-to-noise ratio performances of an amplify-forward relay link and a direct link in a wireless sensor network. For a slow Rayleigh fading channel, an exact expression for the probability that the SNR of an amplify-forward relay link ...
Viswanathan, R.
core +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Relay Switching Aided Turbo Coded Hybrid-ARQ for Correlated Fading Channel
, 2011 Hybrid-Automatic-Repeat-reQuest (HARQ) has become an indispensable technique in reliable communications systems. However, its performance is inevitably affected by the channel’s fading correlation. In this paper, we proposed a novel relay-switching aided
Maunder, Robert +5 more
core +1 more source