Results 71 to 80 of about 371,406 (280)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Localizing Noncooperative Receiver Through Full-Duplex Amplify-and-Forward Relay

IEEE Access, 2018
Localizing noncooperative transmitter (Tx) and receiver (Rx) that belong to another system is important in many scenarios, e.g., interference management in cognitive radio systems and user behavior learning in ad hoc wireless networks. However, obtaining
Chuanxue Jin, Bo Chang, Guodong Zhao, Zhi Chen, Yuan Shen   +4 more
doaj   +1 more source

Optimal Relay Selection Scheme Based on Hybrid Decode-Amplify-and-Forward [PDF]

Jisuanji gongcheng, 2017
In order to extend the network life on the base of lower Symbol Error Rate(SER),a relay selection scheme based on Hybrid Decode-Amplify-and-Forward(HDAF) relaying method is proposed.Joint optimization function about receiving Signal to Noise Ratio(SNR ...
SUN Wensheng,LI Leyuan
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Optimal Power Allocation for Parameter Tracking in a Distributed Amplify-and-Forward Sensor Network

, 2014
We consider the problem of optimal power allocation in a sensor network where the sensors observe a dynamic parameter in noise and coherently amplify and forward their observations to a fusion center (FC).
Chen, Jie, Jiang, Feng, Swindlehurst, A. Lee   +2 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dual-hop amplify-and-forward multi-relay maximum ratio transmission

Journal of Communications and Networks, 2016
In this paper, the performance of dual-hop multi-relay maximum ratio transmission (MRT) over Rayleigh flat fading channels is studied with both conventional (all relays participate the transmission) and opportunistic (best relay is selected to maximize the received signal-to-noise ratio (SNR)) relaying.
Erdogan, Eylem, Gucluoglu, Tansal
openaire   +4 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

All-Optical Amplify-and-Forward Relaying System for Atmospheric Channels

IEEE Communications Letters, 2012
In this letter, we investigate the performance of a dual-hop free space optical link with an all-optical amplify-and-forward relay. We employ photon counting methodology and derive closed form expressions for the end-to-end signal-to-noise ratio and the outage probability. In our derivations, we consider either full or partial channel state information
Mohammadreza A. Kashani, Mohammad M. Rad, Majid Safari, Murat Uysal   +3 more
openaire   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source