Results 71 to 80 of about 395,124 (322)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Optimal space-time codes for the MIMO amplify-and-forward cooperative channel

, 2006
In this work, we extend the non-orthogonal amplify-and-forward (NAF) cooperative diversity scheme to the MIMO channel. A family of space-time block codes for a half-duplex MIMO NAF fading cooperative channel with N relays is constructed.
Belfiore, Jean-Claude, Yang, Sheng
core   +7 more sources

Cooperative Relay in Cognitive Radio Networks: Decode-and-Forward or Amplify-and-Forward? [PDF]

2010 IEEE Global Telecommunications Conference GLOBECOM 2010, 2010
Cognitive radios (CR) and cooperative communications represent new paradigms that both can effectively improve the spectrum efficiency of future wireless networks. In this paper, we investigate the problem of cooperative relay in CR networks for further improved network performance.
Donglin Hu, Shiwen Mao
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Ergodic capacity of the exponentially correlated slotted amplify and forward relay channel [PDF]

, 2012
In this paper we analyze the performance degradation of slotted amplify-and-forward protocol in wireless environments with high node density where the number of relays grows asymptotically large.
Jayalath, Dhammika, O'Shea, Peter, Widanagamage, Anushka   +2 more
core   +1 more source

Outage Capacity of Bursty Amplify-and-Forward with Incremental Relaying

, 2010
We derive the outage capacity of a bursty version of the amplify-and-forward (BAF) protocol for small signal-to-noise ratios when incremental relaying is used.
Goldsmith, Andrea, Gunduz, Deniz, Jaekel, Holger, Jondral, Friedrich, Renk, Tobias   +4 more
core   +1 more source

Toward Optimal Power Control and Transfer for Energy Harvesting Amplify-and-Forward Relay Networks

IEEE Transactions on Wireless Communications, 2018
In this paper, we study an amplify-and-forward relay network with energy harvesting (EH) source and relay nodes. Both nodes can continuously harvest energy from the environment and store it in batteries with finite capacity. Additionally, the source node
Keshav Singh, Meng-Lin Ku, Jia-Chin Lin, T. Ratnarajah   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploiting Sparsity in Amplify-and-Forward Broadband Multiple Relay Selection

IEEE Access, 2019
Cooperative communication has attracted significant attention in the last decade due to its ability to increase the spatial diversity order with only single-antenna nodes.
Ala Gouissem, Ridha Hamila, Naofal Al-dhahir, Sebti Foufou   +3 more
doaj   +1 more source