Results 121 to 130 of about 1,296 (182)
Effect of amrinone on myocardial mitochondria function [PDF]
FEBS Letters, 1988 The effect of amrinone on cardiac mitochondria of guinea pig was studied. It was found that amrinone does not change the respiratory function of cardiac mitochondria in the presence of alpha-ketoglutarate, whereas it inhibits glutamate oxidation.
Cristina Mussini
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Effects of amrinone on bilateral renal ischemia/reperfusion injury
Urological Research, 2002 Renal ischemia/reperfusion injury could arise as a consequence of clinical conditions such as renal transplantation. shock, cardiac arrest. hemorrhage and renal artery surgery. In this experimental study.
Gülşen Ekingen +2 more
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Clinical Pharmacology and Therapeutics, 1981
High-performance liquid chromatographic methods for the analysis of amrinone in plasma and for both amrinone and its N-acetyl metabolite in urine were developed and applied to measure specimens obtained from a number of healthy men who had received intravenous or oral amrinone. The intravenous doses ranged from 0.8 to 2.2 mg/kg. Terminal elimination of
M P, Kullberg +4 more
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High-performance liquid chromatographic methods for the analysis of amrinone in plasma and for both amrinone and its N-acetyl metabolite in urine were developed and applied to measure specimens obtained from a number of healthy men who had received intravenous or oral amrinone. The intravenous doses ranged from 0.8 to 2.2 mg/kg. Terminal elimination of
M P, Kullberg +4 more
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International Journal of Experimental Pathology, 1996 The goal of this study was to compare the effects of glucagon and amrinone on mean arterial pressure (MAP) and heart rate, when used alone and in combination, in an anaesthetized rat model of verapamil toxicity.
Sule Kalkan, Yesim Tuncok, Mehmet Ateş
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Dose proportionality of amrinone
Clinical Pharmacology and Therapeutics, 1983Amrinone was given to 18 healthy subjects in doses of 75, 150, and 225 mg in a randomized crossover design. Plasma levels were shown to rise in proportion to dose. The mean plasma AUC, extrapolated to infinite time, was determined for each dose level; the values obtained were 4, 8.18, and 12.35 micrograms .
J, Edelson +5 more
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Electrophysiologic effects of amrinone
The American Journal of Cardiology, 1985Patients with congestive heart failure (CHF) have a high prevalence of complex ventricular arrhythmias. Accordingly, the electrophysiologic effects of new drugs for the treatment of CHF should be studied to determine whether they are safe in this population of patients.
R A, Goldstein +3 more
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Amrinone‐Mediated Thrombocytopenia
Scandinavian Journal of Haematology, 1983Amrinone, a new cardioactive drug, was administered for, on average, 27.9 d to 12 patients in severe congestive heart failure. Thrombocytopenia occurred in 4 patients, while a progressive decline in platelet numbers developed in 3 additional patients.
E L, Kinney +3 more
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Amrinone: pharmacokinetics and pharmacodynamics
Journal of Cardiothoracic Anesthesia, 1989Amrinone is a selective inhibitor of phosphodiesterase fraction 3 in both cardiac and smooth muscle. Intravenous administration in humans produces increased contractility and vasodilation of venous capacitance and arterial conductance vessels. The elimination half-life in healthy patients is reported to be 2.6 to 4.1 hours, making it the only long ...
J H, Levy, J M, Bailey
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Amrinone-Induced Thrombocytopenia
Archives of Internal Medicine, 1984• The frequency and characteristics of thrombocytopenia resulting from administration of amrinone, a new inotropic and vasodilator agent, was evaluated in 43 patients. Thrombocytopenia attributable to amrinone developed in eight patients (18.6%). The thrombocytopenia was due to accelerated peripheral loss of platelets.
J, Ansell +4 more
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Amrinone Pharmacokinetics in Neonates and Infants
The Journal of Clinical Pharmacology, 1988Amrinone is a bipyridine derivative that exerts systemic pulmonary vasodilatory effects while also being a positive inotrope. Amrinone is used frequently to treat pulmonary hypertension, congestive heart failure, and postoperative heart failure. Because there is a direct relationship between plasma amrinone levels and cardiac index,1 knowledge of the ...
S, Lawless +4 more
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