Results 131 to 140 of about 1,170 (185)
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Amrinone Pharmacokinetics in Neonates and Infants
The Journal of Clinical Pharmacology, 1988Amrinone is a bipyridine derivative that exerts systemic pulmonary vasodilatory effects while also being a positive inotrope. Amrinone is used frequently to treat pulmonary hypertension, congestive heart failure, and postoperative heart failure. Because there is a direct relationship between plasma amrinone levels and cardiac index,1 knowledge of the ...
S, Lawless +4 more
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Amrinone-Induced Thrombocytopenia
Archives of Internal Medicine, 1984• The frequency and characteristics of thrombocytopenia resulting from administration of amrinone, a new inotropic and vasodilator agent, was evaluated in 43 patients. Thrombocytopenia attributable to amrinone developed in eight patients (18.6%). The thrombocytopenia was due to accelerated peripheral loss of platelets.
J, Ansell +4 more
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Pharmacokinetics of amrinone in neonates and infants
Journal of Cardiothoracic and Vascular Anesthesia, 2000To evaluate the pharmacokinetics of amrinone and its metabolites in neonates and infants after reconstructive surgery for congenital heart disease.Prospective study.Pediatric intensive care unit in a university hospital.Fifteen neonates aged less than 1 month with transposition of the great arteries and 14 infants aged 2 to 6 months with complete ...
P, Laitinen +5 more
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Dimensions Of Critical Care Nursing, 1990
Intravenous amrinone (Inocor) is the latest in a line of cardiotonic agents approved for the treatment of heart failure. A thorough knowledge of the pharmacology of this agent is essential in the development of a plan of care for this critically ill patient.
D B, Fabius, A, Rein
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Intravenous amrinone (Inocor) is the latest in a line of cardiotonic agents approved for the treatment of heart failure. A thorough knowledge of the pharmacology of this agent is essential in the development of a plan of care for this critically ill patient.
D B, Fabius, A, Rein
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Amrinone: Is it the inotrope of choice?
Journal of Cardiothoracic Anesthesia, 1989In the treatment of acute heart failure, conventional therapy with epinephrine, norepinephrine, dopamine, and dobutamine may be used effectively to treat inotropic abnormalities. However, the addition of a vasodilator to catecholamine therapy may be needed to help improve lusitropic function.
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Hemodynamic Assessment of Amrinone
New England Journal of Medicine, 1978Amrinone, a new bipyridine derivative, exerts a positive inotropic action in experimental preparations and is effective when administered orally to dogs. To assess its immediate effects in man, we studied by cardiac catheterization the hemodynamic responses to amrinone (1.85 to 3.5 mg per kilogram given intravenously) in eight patients with congestive ...
J R, Benotti +4 more
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Metabolism of amrinone in animals.
Drug Metabolism and Disposition, 1982The biotransformation of 14C-amrinone was studied in rats, dogs, and monkeys by automated gradient high-performance liquid chromatography. The major pathways of metabolism elucidated are: A) glucuronidation at the primary amino nitrogen atom and/or the enolized oxygen atom of the pyridone ring; B) addition of glutathione at the pyridone 2-position and ...
J F, Baker +5 more
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Historical perspectives and update of amrinone
Journal of Cardiothoracic Anesthesia, 1989The pathophysiological understanding and management of acute and chronic heart failure have changed dramatically in the past decade. Since the early 1980s, a major effort has been made to develop nonglycosidic, noncatecholamine agents that combine inotropic and vasodilating properties, in order to treat myocardial dysfunction unresponsive to current ...
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Reduction of Lethal Toxicity of Doxorubicin by Amrinone
Tumori Journal, 1982Administration of attirinone, a new inotropic agent, markedly reduced acute lethal toxicity in normal female Swiss and male BALB/c mice given lethal doses of doxorubicin. Because attirinone abolished the negative inotropic effect of doxorubicin in isolated guinea pig atria, it was suggested that partial protection from acute toxicity of the antitumor ...
Bossa, R +4 more
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Toxicological Studies with Amrinone
1988Amrinone, 3-amino-5-(pyrid-4yl)-1,2-dihydropyridine-2one, an inhibitor of phosphodiesterases with positive inotropic and vasodilator activity, represents a prototype of a new class of drugs against cardiac failure (Alousi et al. 1979; Alousi and Farah 1980; Landmann and Loewe 1986). Its therapeutic value is limited because of multiple side-effects. The
H. Landmann, I. Frosch
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