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Pharmacokinetics of amrinone in neonates and infants
Journal of Cardiothoracic and Vascular Anesthesia, 2000To evaluate the pharmacokinetics of amrinone and its metabolites in neonates and infants after reconstructive surgery for congenital heart disease.Prospective study.Pediatric intensive care unit in a university hospital.Fifteen neonates aged less than 1 month with transposition of the great arteries and 14 infants aged 2 to 6 months with complete ...
P, Laitinen +5 more
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Dimensions Of Critical Care Nursing, 1990
Intravenous amrinone (Inocor) is the latest in a line of cardiotonic agents approved for the treatment of heart failure. A thorough knowledge of the pharmacology of this agent is essential in the development of a plan of care for this critically ill patient.
D B, Fabius, A, Rein
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Intravenous amrinone (Inocor) is the latest in a line of cardiotonic agents approved for the treatment of heart failure. A thorough knowledge of the pharmacology of this agent is essential in the development of a plan of care for this critically ill patient.
D B, Fabius, A, Rein
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Hemodynamic Assessment of Amrinone
New England Journal of Medicine, 1978Amrinone, a new bipyridine derivative, exerts a positive inotropic action in experimental preparations and is effective when administered orally to dogs. To assess its immediate effects in man, we studied by cardiac catheterization the hemodynamic responses to amrinone (1.85 to 3.5 mg per kilogram given intravenously) in eight patients with congestive ...
J R, Benotti +4 more
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Amrinone: Is it the inotrope of choice?
Journal of Cardiothoracic Anesthesia, 1989In the treatment of acute heart failure, conventional therapy with epinephrine, norepinephrine, dopamine, and dobutamine may be used effectively to treat inotropic abnormalities. However, the addition of a vasodilator to catecholamine therapy may be needed to help improve lusitropic function.
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Metabolism of amrinone in animals.
Drug Metabolism and Disposition, 1982The biotransformation of 14C-amrinone was studied in rats, dogs, and monkeys by automated gradient high-performance liquid chromatography. The major pathways of metabolism elucidated are: A) glucuronidation at the primary amino nitrogen atom and/or the enolized oxygen atom of the pyridone ring; B) addition of glutathione at the pyridone 2-position and ...
J F, Baker +5 more
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Reduction of Lethal Toxicity of Doxorubicin by Amrinone
Tumori Journal, 1982Administration of attirinone, a new inotropic agent, markedly reduced acute lethal toxicity in normal female Swiss and male BALB/c mice given lethal doses of doxorubicin. Because attirinone abolished the negative inotropic effect of doxorubicin in isolated guinea pig atria, it was suggested that partial protection from acute toxicity of the antitumor ...
Bossa, R +4 more
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Historical perspectives and update of amrinone
Journal of Cardiothoracic Anesthesia, 1989The pathophysiological understanding and management of acute and chronic heart failure have changed dramatically in the past decade. Since the early 1980s, a major effort has been made to develop nonglycosidic, noncatecholamine agents that combine inotropic and vasodilating properties, in order to treat myocardial dysfunction unresponsive to current ...
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[Experimental and clinical pharmacokinetics of amrinone].
Cardiologia (Rome, Italy), 1982Articolo sperimentale nell'uomo circa l'amrinone, in un tempo nel quale tale farmaco era considerato avveniristico. Ampia descrizione delle sue proprietà farmacocinetiche in campo umano, con messa a punto di un metodo per la determinazione delle concentrazioni.
PADRINI, ROBERTO +4 more
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